Protein Kinase C
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This paper provides a brief descriptive overview of the enzyme protein kinase C, a ubiquitous family of enzymes involved in a number of cellular processes including growth and differentiation, ion channel regulation, neuronal plasticity and memory storage. The paper then discusses its definition, structure, functions, properties, role, reactions, regulation and mutation.
From the Paper:"Protein Kinase C (PKC) was first was first identified in 1977 as a proteolytically activated protein kinase. As research progressed it became known as ubiquitous in tissues and organs. The enzyme PKC requires calcium and a phospholipid -phosphatidylserine, for activation as well as diacylglycerol. During the cell cycle the calcium is derived from the IP3 pathway, and the diacylglycerol, binds to the PKC, and increases the affinity of the enzyme for calcium. This done the PKC is able to be fully active without a net increase in the calcium concentration of the cytosol. Another aspect to note is that the sn-1,2-diacylglycerol is active towards PKC, neither of the other isoforms play a role, and those DAGs with an unsaturated fatty acid tail are most active suggests that highly specific lipid-protein interaction is needed for the enzyme activation."
Cite this Term Paper:
Protein Kinase C (2003, October 07) Retrieved November 25, 2020, from https://www.academon.com/term-paper/protein-kinase-c-36391/
"Protein Kinase C" 07 October 2003. Web. 25 November. 2020. <https://www.academon.com/term-paper/protein-kinase-c-36391/>