Motility of Mammalian Intestinal Smooth Muscle Term Paper

A look at a study about intestinal smooth muscle.
# 152027 | 1,060 words | 11 sources | APA | 2012 | US

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This paper describes an experiment on in vitro movement of intestinal smooth muscle. According to the paper, studying this tissue should illuminate information concerned with intestinal smooth muscle contractions and neurotransmitter receptor activity. First, the paper describes the experimental model, the hypothesis and the drugs that are to be tested on the tissue. Detailed information is given about the four drugs that are used in the study, which are acetylcholine bromide, adrenalin tartrate, atropinesulphate, and eserine. Next, the paper describes the results of the experiment. The paper concludes by summarizing the effects of the various drugs on intestinal motility.


Introduction and Background of Practical
Modes and Methodology of Drugs

From the Paper:

"In this experiment, four drugs were under study: acetylcholine bromide, adrenalin tartrate, atropine sulphate, and eserine. Each drug will now be discussed in connection with their modes of reaction. Acetylcholine (ACh) is a neurotransmitter that is released by peripheral neurons system neurons and central nervous system neurons. It can act both as an excitatory neurotransmitter and as an inhibitory neurotransmitter. It opens cation channels at the neuromuscular junction, but also acts indirectly on ion channels that link to a G protein (Popcock, 2006). It also slows the heart rate at inhibitory synapses. The mode by which ACh works will now be explained. An action potential must first arrive at the axon terminal. Sodium channels then open which causes the opening of calcium channels. Calcium enters the cell and causes acetylcholine vesicles to fuse with the presynaptic membrane (Popcock, 2006). The ACh molecules then diffuse across the synaptic cleft and bind to the postsynaptic membrane. Cation channels are opened by activated receptors and depolarization of the postsynaptic membrane occurs. This causes an action potential in the postsynaptic membrane and, finally, ACh is broken down and the presynaptic cell takes the components back up and recycles them..."

Sample of Sources Used:

  • Furness, J.B. and Costa., M. (1980). Types of nerves in the enteric nervous system. U.S.A: Neuroscience
  • Gharpure, M.B. (1964). The Acetylcholine-Atropine Antagonism as Determined By Very High PA Values. U.S.A: Indian J Med Res
  • Kitazawa, T., Kondo, H., and Temma, K. (1986). Alpha 2-adrenoceptor-mediated contractile response to catecholamines in smooth muscle strips isolated from rainbow trout stomach (Salmo gairdneri). U.S.A: Br J Pharmacol
  • Nirmalan, Niroshini. (2010). Motility of Mammalian Intestinal Smooth Muscle. U.K
  • Obreshkove, Vasil. (1941). The Action of Acetylchoine, Atropine and Physostigmine on the intestine of Daphnia Magna. U.S.A.: Marine Biological Laboratory

Cite this Term Paper:

APA Format

Motility of Mammalian Intestinal Smooth Muscle (2012, November 13) Retrieved February 07, 2023, from

MLA Format

"Motility of Mammalian Intestinal Smooth Muscle" 13 November 2012. Web. 07 February. 2023. <>