Vitamin D Deficiency and Related Insulin Resistance and Inflammation Research Proposal by Nicky

The paper proposes research to examine the relationship between vitamin D deficiency (hypovitaminosis D) and diabetes, inflammation and resistance to insulin.
# 145379 | 1,997 words | 11 sources | MLA | 2010 | US

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This paper presents a research proposal to establish a causal relation between hypovitaminosis D and insulin resistance, diabetes, and systemic inflammation. The paper seeks to augment the research data (and substantial anecdotal evidence) currently available implicating hypovitaminosis D in these conditions. Additionally, the paper seeks to devise a research method for distinguishing the respective beneficial roles of vitamin D and calcium in light of current evidence suggesting that dual supplementation is associated with greater preventative effects than supplementation of one or the other alone.

From the Paper:

"Prior to the widespread vitamin and mineral supplementation of modern food supplies, rickets and the skeletal weakness for which that disease is responsible was a formidable medical condition. Once rickets was substantially eradicated by vitamin supplementation in modern food processing, many medical authorities considered that solution to have eliminated all of the consequences of vitamin D deficiency. More recently, medical researchers have identified so many other significant medical consequences attributable to hypovitaminosis D that contemporary clinicians now regard rickets as only the tip of the proverbial iceberg of vitamin D-related ailments"

Sample of Sources Used:

  • Barger-Lux MJ, Heaney RP, Dowell S, Chen TC, Holick MF. "Vitamin D and its Major Metabolites: Serum Levels after Graded Oral Dosing in Healthy Men." Osteporos Int 1998; 8:222-30.
  • Chiu KC, Chu A, Go VL, Saad MF. "Hypovitaminosis D Is Associated with Insulin Resistance and Beta Cell Dysfunction." Am J Clin Nutr 2004; 79:820-5.
  • Dakovska L, Kovacheva R. The Effect of Vitamin D3 on Insulin Secretion and Peripheral Insulin Sensitivity in Type 2 Diabetic Patients. Int J Clin Pract 2003; 57: 258-26
  • Holick MF. "Vitamin D Deficiency." N Engl J Med 2007; 357:266-81.
  • Mathieu C, Adorini L. "The Coming of Age of 1,25-Dihydroxyvitamin D(3) Analogs as Immunomodulatory Agents." Trends Mol Med 2002; 8: 174-9.

Cite this Research Proposal:

APA Format

Vitamin D Deficiency and Related Insulin Resistance and Inflammation (2010, November 07) Retrieved December 06, 2021, from

MLA Format

"Vitamin D Deficiency and Related Insulin Resistance and Inflammation" 07 November 2010. Web. 06 December. 2021. <>