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The paper explores the current body of research concerning the potential benefits of statins for Alzheimer's patients. The paper then presents a proposal to further examine the possibilities that lie in the use of statins in patients with Alzheimer's disease.
From the Paper:"Literature regarding the use of statins in the reduction of high cholesterol and the prevention of heart disease is abundant. However, only a small number of research studies exist regarding the use of statins in Alzheimer's patients. The potential for using statins in this manner is based on evidence that high cholesterol is linked to the development of Alzheimer's disease, as well as coronary artery disease (Sparks, 2002). This supposition is supported by a study that indicates a reduction in Alzheimer's Disease biomarkers in cerebrospinal fluid (Riekse, Li, & Petrie et al, 2006). Post-mortem studies also indicated a reduction in Alzheimer's Disease among statin users (Li, Larson, & Sonnen et al, 2007)."
Sample of Sources Used:
- Algotsson, A. & Winblad, B. (2004). Patients with Alzheimer's Disease May Be Particularly Susceptible to Adverse Effects of Statins. Dement Geriatr Cogn Disord. 17: 109-116. PubMed.
- Hoglund, K. & Blennow, K. (2007). Effect of HMG-CoA reductase inhibitors on -amyloid peptide levels : Implications for Alzheimer's disease. CNS drugs. 21 (6): 449-462. PubMed.
- Jick, H., Zornberg, G., & Jick, S. et al. (2000). Statins and the risk of dementiaThe Lancet. 356 (9242): 1627-1631 PubMed
- Li, G., Higdon, R., & Kukull W. et al. (2004). Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study. Neurology. 63 (9): 1624-1628. PubMed.
- Li, G., Larson, E. & Sonnen, J. et al. (2007). Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology. 69 (9): 878-875. PubMed.
Cite this Research Proposal:
Statin Use in Alzheimer's Patients (2010, November 23) Retrieved September 24, 2020, from https://www.academon.com/research-proposal/statin-use-in-alzheimer-patients-145696/
"Statin Use in Alzheimer's Patients" 23 November 2010. Web. 24 September. 2020. <https://www.academon.com/research-proposal/statin-use-in-alzheimer-patients-145696/>