Haemapoietic Stem Cell Sources in Transplantation Research Paper by Jay Writtings LLC

Haemapoietic Stem Cell Sources in Transplantation
An in-depth study of stem-cell use in bone marrow transplantation (BMT).
# 120124 | 5,592 words | 54 sources | APA | 2010 | US
Published on Jun 04, 2010 in Biology (Molecular and Cell) , Medical and Health (Medical Studies)

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This in-depth research paper gives an extensive, detailed view of stem-cell use in bone marrow transplantation (BMT). The paper covers donor registries, cord blood banking, and transplant-related mortality, including comparison tables for various stem cell types. The paper concludes that despite considerable progress in BMT over the years, some of the major obstacles like graft-versus-host disease (GVHD), failure to engraft and lack of suitable donors, continue to be major stumbling blocks.

I. Introduction
II. Application of SCs in Transplantation
Type of SC transplants available
Availability & collection of different sources
Bone marrow registries
Cord blood banks
Donor search
Growth factors
PBSC harvesting
Cord blood harvesting
Risks for donors
Ethical issues regarding the sources
III. Outcome of SC transplantation
Factors affecting the outcome
Conditioning regimen
Non-myeloablative allogeneic HSCT
Time for engraftment or immune reconstitution
Transplant related mortality
Role of HLA compatibility
Effect of other cells in the graft in GVHD and GVL, and the balance of GVHD and GVL

From the Paper:

"Until now, there has been no direct evidence for a GVL effect in humans (Burakoff, 1997). Recently, direct evidence has been provided by the infusion of donor leukocytes. Administering donor lymphocyte infusion (DLI) after SCT has emerged as an effective way of separating GVHD from GVL effects (Ferrara, Cooke & Deeg, 2004.)
"DLI infusions have been shown to be effective to induce remissions in chronic myeloid leukaemia, acute myeloid leukaemia and multiple myeloma, and in some cases of acute lymphoblastic leukaemia and myelodysplastic syndrome. The same T cells that mediate GVHD may also be responsible for the GVL effect. In closely matched donor/recipient pairs, there may be the presence of donor T cells that are capable of more specific recognition of leukaemic cells, which leads to complete remissions without GVHD following DLI. On the other hand, if the degree of mismatch between the donor and recipient increases, the frequency of alloreactive T cells increases, leading to a negative balance between GVHD and GVL effects (Barrett & Jiang, 2000.)"

Sample of Sources Used:

  • Antin, J.H. (2001) Acute graft-versus-host disease: inflammation run amok? J Clin Invest, 107, 1497-1498.
  • Appelbaum, F.R. (2003) The current status for hematopoietic cell transplantation. Annu. Rev. Med, 54, 491.
  • Arai, S., Klingemann, H.G., (2003) Hematopoietic Stem Cell Transplantation: Bone Marrow vs. Mobilized Peripheral Blood. Arch Med Res, 34, 545.
  • Australian Academy of Science (2001) Human stem cell research. www.science.org.au/reports/stemcell.pdf p.10.
  • Austen, K.F, Rosen, F.S, Burakoff, S.J & Strom, T.B., (2001) In: Therapeutic Immunology, 2nd ed. p. 508. Blackwell Publishing.

Cite this Research Paper:

APA Format

Haemapoietic Stem Cell Sources in Transplantation (2010, June 04) Retrieved April 10, 2020, from https://www.academon.com/research-paper/haemapoietic-stem-cell-sources-in-transplantation-120124/

MLA Format

"Haemapoietic Stem Cell Sources in Transplantation" 04 June 2010. Web. 10 April. 2020. <https://www.academon.com/research-paper/haemapoietic-stem-cell-sources-in-transplantation-120124/>