Diagnosing Myasthenia Gravis Research Paper by Nicky

A review of the available diagnostic tests for myasthenia gravis and their sensitivities and specificities.
# 151025 | 5,663 words | 31 sources | APA | 2012 | US
Published on May 18, 2012 in Medical and Health (General)

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The paper looks at the epidemiology of myasthenia gravis and its signs and symptoms, its pathophysiology and diagnostic tests. The paper explores the literature on repetitive facial-nerve stimulation in patients with myasthenia gravis and includes several tables and figures.

Symptoms and Signs
Diagnostic Tests
Ice and Rest Tests
Antibody Testing
Single Fiber Electromyography
Repetitive Facial -Nerve Stimulation in Patients with Myasthenia Gravis

From the Paper:

"Symptoms and signs of myasthenia include weakness "without atrophy, pain, sensory loss or reflex changes." (Ahmadi and Barton, 2005) Stated as the two classic features of myasthenic weakness are variability, because the weakness changes over days or even minutes and the patient experiences a shift between varying muscles accompanied by fatigue meaning that "the weakness worsens with repeated use and improves with rest." (Ahmadi and Barton, 2005)
"Weakness often affects "bulbara, facial and extra-ocular muscles" and "up to two thirds of patients initially present with diplopia or ptosis and nearly all will have diplopia or ptosis at some point." (Ahmadi and Barton, 2005) It is stated that approximately 25% of patients "present bulbar symptoms such as nasal slurred speech, or difficulty chewing and swallowing. Limb involvement is the initial complaint in a minority, about 14-27%. The symptoms of myasthenia are often better upon awakening or after rest and will be worse after prolonged use of affected muscle later in the course of the day Among the different symptoms, only two have been studied for their predictive value for myasthenia: presence of food remaining in mouth after swallowing and speech becoming unintelligible during prolonged speaking. Neither normal swallowing nor normal speech rules out myasthenia gravis." (Ahmadi and Barton, 2005)"

Sample of Sources Used:

  • Ahmadi, Amir Ali and Barton, Jason (2009) Ocular Myasthenia. The Canadian eTextbook of Eye Movements - C. Clinical Disorders. University of British Columbia, January 2009. Online available at: http://www.neuroophthalmology.ca/textbook/myasthenia.html
  • Ahmadi, Amir Ali and Barton, Jason (2009) Ocular Myasthenia. The Canadian eTextbook of Eye Movements - C. Clinical Disorders. Online available at: http://www.neuroophthalmology.ca/textbook/myasthenia.html
  • Barton J, Huaman A, Sharpe J. Effect of edrophonium on saccadic peak velocities in myasthenic and non-myasthenic ocular palsies and normal subjects. Ann Neurol. 1994;36:585-94.
  • Barton J, Sharpe J. 'Saccadic jitter' is a quantitative ocular sign in myasthenia gravis. Invest Ophthalmol Visual Sci. 1995;36:1566-72.
  • Barton J. Quantitative ocular tests for myasthenia gravis: a comparative review with detection theory analysis. J Neurol Sci. 1998;155:104-14.

Cite this Research Paper:

APA Format

Diagnosing Myasthenia Gravis (2012, May 18) Retrieved January 28, 2022, from https://www.academon.com/research-paper/diagnosing-myasthenia-gravis-151025/

MLA Format

"Diagnosing Myasthenia Gravis" 18 May 2012. Web. 28 January. 2022. <https://www.academon.com/research-paper/diagnosing-myasthenia-gravis-151025/>