Battling Bacterial Biofilms Research Paper by JohWil

An exploration of the general molecular and cellular aspects of biofilm formation and a focus on manners that can be applied to tackle biofilms incorporating quorum sensing.
# 145366 | 3,318 words | 14 sources | APA | 2010
Published on Nov 05, 2010 in Biology (Molecular and Cell)

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This paper discusses the general molecular and cellular aspects of biofilm formation. It describes how bacteria can form mulitcellular communities on solid surfaces that are known as biofilms. This behavior leads to a coordinated control of virulence and biofilm formation. These elements within the biofilm appear to be regulated by density dependant communication called quorum sensing. This paper provides an understanding of how biofilms are built up as well as how they function and develop. It also explains how understanding the way biofilms are built up is pivotal for human health because many diseases that are acquired in hospital environments are based on biofilm forming bacteria that often cannot be counteracted with conventional antimicrobials.

Table of Contents:
Introduction: A brief overview over biofilm history, structure and formation and the conflicting relationship between humans and biofilms
Discussion: Reasons for the pathogenic potential, resistances and different health issues caused by biofilms and ways to inhibit them
Virulence factors of the bacterium Pseudomonas aeroginosa are controlled by quorum sensing
Staphylococcal infections can be prevented by the use of quorum sensing inhibitors
The lifestyle of Vibrio cholerae depends greatly on quorum sensing
Conclusion: A critical look back on solutions and possible insights which might be achieved in the future

From the Paper:

"As indicated above, biofilms are not just bacteria attached to a surface, but stationary colonies with metabolically, morphologically and physiologically distinct features that differ significantly from planktonic bacteria, causing challenges in treating biofilm related diseases. At the same time this opens up therapeutical possibilities to inhibit biofilm formation. First, the role of P. aeroginosa and its biofilms formed by QS in cystic fibrosis pneumonia was discussed. This pathogen can be inhibited by the synthetic QSI C-30 which is an autoinducer antagonist. In the following, I explained the Staphylococcal QS circuit in order to inhibit biofilms by means of inhibiting the virulence factor forming RNAIII with help of the RIP molecule. I finished with QS controlling biofilm formation in V. cholerae which can in contrast to the other examples possibly be counteracted by the use of QS enhancers."

Sample of Sources Used:

  • Balaban N, Goldkorn T, Gov Y, Hirshberg M, Koyfman N, Matthews HR, Nhan RT, Singh B, Uziel O. 2001. Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating protein (TRAP). Journal of Biological Chemistry 276(4):2658-2667.
  • Balaban N, Stoodley P, Fux CA, Wilson S, Costerton JW, Dell'Acqua G. 2005. Prevention of staphylococcal biofilm-associated infections by the quorum sensing inhibitor RIP. Clinical orthopaedics and related research 437:48-54.
  • Bassler BL. 1999. How bacteria talk to each other: regulation of gene expression by quorum sensing. Current Opinion in Microbiology 2(6):582-587.
  • Bassler BL, Greenberg EP, Stevens AM. 1997. Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi. Journal of Bacteriology 179(12):4043-4045.
  • Costerton JW, Stewart PS, Greenberg EP. 1999. Bacterial biofilms: a common cause of persistent infections. Science 284(5418):1318-1322.

Cite this Research Paper:

APA Format

Battling Bacterial Biofilms (2010, November 05) Retrieved December 03, 2021, from

MLA Format

"Battling Bacterial Biofilms" 05 November 2010. Web. 03 December. 2021. <>