IV Aspirin for the Myocardial Infarction Patient Dissertation or Thesis by Nicky

IV Aspirin for the Myocardial Infarction Patient
Reports an original study using the VerifyNow platelet function assay to formulate IV aspirin for administration to patients with acute myocardial infarction.
# 149640 | 13,850 words | 26 sources | APA | 2011 | US

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This paper explains that, although aspirin has been found in many to be effective in treating patients with heart disease including myocardial infarction, many patients cannot successful take aspirin due to complicating factors that result in bleeding being triggered by aspirin. Next, the author presents an extensive literature review, the methodology for the original study and the results in table format. The paper concludes that this study found that aqueous solutions of acetylsalicylic acid (ASA) hydrolyzes rapidly, which correlates with a diminished 'ex vivo' ASA effect on platelet function. The paper includes 22 figures and three tables.

Table of Contents:
Table of Contents
List of Tables and Figures
Background of the Study
Statement of the Problem
Purpose of the Study
Organization of the Study
Terms and Definitions
Literature Review
Anti-Platelet Effects of Aspirin
VerifyNow Assay
Methodology, Results, Summary and Conclusion
Results of Study
Summary of Results
Conclusions of the Study

From the Paper:

"The work of Hillman (2009) entitled: "Platelet Aspirin Resistance Detection and Validation" states that it was concluded by Tantry et al that the occurrence of aspirin resistance "in published reports is overestimated, implying that this was due to the use of assays that did not measure cyclooxygenase-1 (COX-1) activity. Although these investigators reported an incidence of aspirin resistance of _0.4%, several reviews estimate, based on a large number of studies, that the incidence of aspirin resistance is between 5% and 45%." There are stated to be serious limitations in the Tantry et al study that "call into question the generalizability of their findings." Stated first is that the research population of Tantry et al was comprised mainly of patients with stable angina. It is stated that a number of studies have demonstrated that "...aspirin resistance is more prevalent in patients with acute coronary syndromes than in patients with stable angina, and thus their study may underestimate the prevalence of aspirin resistance in those at greatest risk."
"Stated secondly is that through "...employing a dose of 325 mg of aspirin, their data may not be applicable to the vast majority of patients who currently are treated with 81 mg per day." Third stated is that because their definition of aspirin resistance "...has not been validated against clinical outcomes, it is arbitrary and thus must be viewed as speculative. Fourth, the thrombelastograph (TEG) assay they use has not undergone extensive critical evaluation.""

Sample of Sources Used:

  • Jawaid, Shaukat Ali (2006) Under Use of Aspirin in Acute Coronary Syndromes. Pakistan Journal of Medical Sciences. Vol. 22, No. 3 July -Sept 2006. Online available at: http://pjms.com.pk/issues/julsep06/article/editorial1.html
  • Anti-Platelet Effects of Aspirin (2009) Healthcare Professional Information. DISPRIN. Online available at: http://www.disprin.com/hcare/antplat/index.htm
  • Myocardial Infarction After Aspirin Treatment, and Kounis Syndrome (2005) RedOrbit. 22 June 2005. Online available at: http://www.redorbit.com/news/health/157465/myocardial_infarction_after_aspirin_treatment_and_kounis_syndrome/
  • Chan, WK (nd) Reappraisal of Long Term Tolerance of Aspirin in Patients after Myocardial Infarction. Department of Medicine & GeriatricsUnited Christian Hospital. Online available at: http://sunzi1.lib.hku.hk/hkjo/view/23/2301867.pdf
  • Sakethou, Benjamin, et al (1997) Emergency Department Use of Aspirin in Patients with Acute Myocardial Infarction. Ann Intern Med. 1997; 127: 126-129. 15 July 1997. Vol. 127 No.2.

Cite this Dissertation or Thesis:

APA Format

IV Aspirin for the Myocardial Infarction Patient (2011, December 27) Retrieved February 07, 2023, from https://www.academon.com/dissertation-or-thesis/iv-aspirin-for-the-myocardial-infarction-patient-149640/

MLA Format

"IV Aspirin for the Myocardial Infarction Patient" 27 December 2011. Web. 07 February. 2023. <https://www.academon.com/dissertation-or-thesis/iv-aspirin-for-the-myocardial-infarction-patient-149640/>