Transforming Growth Factor (TGFa) Signaling Pathway Article Review by Quality Writers

Transforming Growth Factor (TGFa) Signaling Pathway
This paper is an article review of the research by Z. Xaio, X. Liu, YI Henis, and HF Lodish entitled 'A Distinct Nuclear Localization Signal in the N Terminus of Smad 3 Determines Its Ligand-Induced Nuclear Translocation'.
# 99235 | 850 words | 3 sources | APA | 2007 | US
Published on Nov 01, 2007 in Biology (Molecular and Cell) , Chemistry (Biochemistry)

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This paper explains that transforming growth factor TGFa is one member of a large family of proteins that are secreted from different types of cells and regulate growth, differentiation and development. The author points out that the binding of TGFa to its receptor on target cells initiates a series of events that result in changes in gene transcription of specific genes. The paper describes the reported experiment and concludes that its results provide added information to the current knowledge base on Smads, Growth Factor - signaling and the translocation process.

Table of Contents
Aim of the Research Study
Experiments Performed

From the Paper:

"Xaio et al. (2000) performed their experiments on Smad 3 and Smad 4 protein structures that they cloned in a laboratory. This was the beginning of a long chain of events that allowed for assessing the reaction of the proteins before and after transaction . A group of control/stable cell lines was also used to transect the various GFP Smad proteins and constructs. Smad3 and Smad 4 proteins were also exposed to site-directed mutagenesis in order to mimic Smad 4's variation of Lys to Glu. Florescent microscopy was utilized to photograph the cells throughout the process before and after transaction."

Sample of Sources Used:

  • Alberts B, Johnson A, Lewis J, Raff M, Roberts, K Walter, P. 2002. Molecular Biology of the Cell. 4th ed. New York (NY): Garland Science Publishing; 887-889 p.
  • Padgett RW, Cho S, Evangelista C. 1998. Smads are the central component in transforming growth factor- signaling. Phamacol. Ther. 78 (1): 47-52.
  • Xaio Z, Liu X, Henis YI, Lodish HF. 2000. A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation. PNAS. 97 (14): 7853-7858.

Cite this Article Review:

APA Format

Transforming Growth Factor (TGFa) Signaling Pathway (2007, November 01) Retrieved May 29, 2020, from

MLA Format

"Transforming Growth Factor (TGFa) Signaling Pathway" 01 November 2007. Web. 29 May. 2020. <>