Article: "In Vivo Killing of Staphylococcus" Article Review

Reviews the article by Parjam Zolfaghari et al., 'In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent and its significance within the context of related studies."
# 151648 | 800 words | 4 sources | MLA | 2009 | PH

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This paper explains that the 2009 article published in "BMC Microbiology"by Parjam Zolfaghari, et al., 'In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent', studied how a particular light-activated antimicrobial substance might destroy a methicillin-resistant strain of S. aureus (MRSA). Next, the author specifies that the researchers aimed to evaluate the effects of using PDT with methylene blue as a photosensitizer on the epidemic EMRSA-16 strain in superficial and excisional mice wounds and to evaluate the local effect of heating when linked with the PDT-methylene blue treatment. The paper concludes that the importance of this research by Zolfaghari, et al. lies in its pioneering exploration of the in vivo applicability of the PDT-with-antimicrobial treatment of S. aureus (wound) infections.

From the Paper:

"Results showed that the viable EMRSA-16 bacteria taken from the wounds were considerably reduced following irradiation in methylene blue presence: 25 tines at the excision wounds and 14 times at the superficial wounds. With the mice wound models reflecting an infectious process' early stages and he MRSA strain being a known wound infection agent, the study results proves the possibility of EMRSA control or reduction in live wound with the use of PDT with methylene blue. For Zolfaghari, et al., this indicates how the PDT treatment shows promise as a treatment method for wound infections caused by antibiotic-resistant microbial strains, and also for removing such microbes from carriage sites.
"The significance of this study by Zolfaghari, et al. can be well appreciated in the light of their introductory assertion that "Increasing reports of resistance to antibiotics and antiseptics, have sparked a wave of research to find alternative antimicrobial strategies." The first part of the quotation is particularly corroborated by Herman, et al. whose work reviews a new MRSA strain transmissible in outpatient settings. Cogen, Nizetas and Gallo also point to the dramatic increase in antibiotic-resistant S. aureus strains as they elaborate on the danger of S. aureus infections in the body."

Sample of Sources Used:

  • Cogen, A., V. Nizeta and R. Gallo. "Skin Microbiota: A Source of Disease or Defence?" British Journal of Dermatology. 158.3 (2008): 442-455.
  • Embleton, Michelle, et al."Selective Lethal Photosensitization of Methicillin-Resistant Staphylococcus Aureus Using An Igg-Tin (IV) Chlorin E6 Conjugate. " Journal of Antimicrobial Chemotherapy 50 (2002), 857-864.
  • Herman, Ronald, et al." Etiology And Treatment of Community-Associated Methicillin-Resistant Staphylococcus aureus. " American Journal of Health-System Pharmacy 65.3 (2008): 219-225.
  • Katsuaki, Taira, et al."Efficacy of Photodynamic Therapy (PDT) Using Na-Pheophorbide .ALPHA. in a Murine Model of Experimental Methicillin-Resistant Staphylococcus aureus (MRSA) Arthritis. " Abstract. Journal of Nihon University Medical Association. 14 April 2009. Web. 000020060806A0205119.php.
  • Zolfaghari, Parjam, et al. "In Vivo Killing of Staphylococcus Aureus Using a Light-Activated Antimicrobial Agent." BMC Microbiology. 9.27 (2009):442-455.

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Article: "In Vivo Killing of Staphylococcus" (2012, August 22) Retrieved March 01, 2021, from

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