Papers on "Glutathione-s-Transferase" and similar term paper topics
Paper #098930 ::
Glutathione-s-Transferase
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This paper discusses various studies that illustrate the function of the glutathione-s-transferase enzyme.
Written in 2007; 1,179 words; 4 sources; MLA;
$ 40.95
Paper Summary:
The paper relates that high levels of dichloroacetate, a drinking water disinfectant and by-product, depleted glutathione-s-transferase's activity in studied rats. The paper reveals that those with a hereditary deficiency in the gene or enzyme appeared to have an increased risk of developing chronic obstructive pulmonary disorder (COPD). The paper looks at a study that connected the glutathione gene to the development of childhood asthma. The paper discusses another study that illustrated the significance of the glutathione gene in delaying the onset of breast cancer.
From the Paper:
"Dichloroacetate or DCA is a drinking water disinfectant and by-product commonly found in municipal water supplies (Saghir 2002). It is a metabolite of chlorinated industrial solvents and many pharmaceuticals. It is quickly and completely absorbed from the gastrointestinal tract and in extensively metabolized in both rodents and humans by major metabolites. Metabolism occurs primarily in the liver, mediated by Glutathione-s-Transferase GST [zeta] (GSTZ-1) (12). DCA inhibits Glutathione and prolonged exposure of rodents to DCA reduces metabolism and depletes immuno-reactive Glutathione protein levels from the liver."
Tags:
cancer asthma lungs DCA detoxification carcinogens mutation gene
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