Papers on "IL-7 and KL" and similar term paper topics

Paper #066984 :: IL-7 and KL
Buy and instantly download this paper now

Explores immunophenotypic isolation and an analysis of human Interleukin-7 and c-kit (KL) ligand producing TEC.

Written in 2006; 1,259 words; 20 sources; MLA; $ 42.95

Paper Summary:

IL-7 and KL are stroma-derived cytokines, both of which are necessary for the proliferation, survival and differentiation of thymocytes. This paper show that the loss of intrathymic IL-7 production may underlie various forms of acquired immunodeficiencies, such as those occurring after BMT, HIV infection or during aging. The paper concludes that data indicates that the CD45- HLA-DRdim TEC are the only intrathymic source of IL-7 and KL in the human thymus. These cells are present in both the cortex and medulla of the thymus and direct infection of the TEC is not a mechanism for impaired thymopoiesis in active HIV infection.

Table of Contents:

Abstract
Introduction
Study Design
FACS Analyses
RT-PCR
Immunostaining
HIV Challenge and Analysis
Results and Discussion
Acknowledgments
References

From the Paper:

"KL exists in both membrane-bound and secreted isoforms, which result from differential splicing. Inclusion of the 6th exon results in a transcript encoding the transmembrane domain of the membrane-bound form.
RT-PCR primers designed to detect each KL isoform as different sized products demonstrated the presence of both transcripts in the CD45- HLA-DRdim populations, but no other sorted populations of thymic cells.11 Since thymocytes express both the IL-7 receptor and c-kit, the expression of both IL-7 and KL by the same TEC infers that the thymocytes are stimulated simultaneously through the IL-7R and c-kit interaction."

Tags: murine BMT thymic stromal cells RNA

More papers on "IL-7 and KL"

1. Paper #084386 :: '7 Habits of Highly Effective People' ( 675 words; 1 source; )
2. Paper #046910 :: ?Series 7: The Contenders? ( 1,028 words; 4 sources; MLA )
3. Paper #027811 :: Inventory Control at 7-Eleven ( 3,510 words; 6 sources; APA )
4. Paper #101064 :: Apollo 7 and 8 Space Missions ( 2,629 words; 10 sources; MLA )
5. Paper #052394 :: Personnel Planning and Selection Tools at 7-Eleven ( 950 words; 4 sources; APA )

About AcaDemon

We have thousands of high-quality term papers, research papers, essays, book reports and dissertations on every topic. At AcaDemon, you can download those term papers to help you write yours! You can be sure that the term paper, essay, book report or research paper, you download are top-quality, competitively priced and high-level work.

Look for more research papers, essays and book reports on IL-7 and KL

This Free Term Paper Abstract is a part of our Term Paper Library. Here you can purchase research papers, examples of essays, academic dissertations, articles, notes, analytical papers, book reports, stories and poems. We have thousands of persuasive, point-of-view, narrative, critical, compare and contrast and other types of essays in our Library. You can also find here Term papers on "IL-7 and KL", Essays on "IL-7 and KL", Research papers on "IL-7 and KL", Student papers on "IL-7 and KL", Book reports on "IL-7 and KL", Dissertation on "IL-7 and KL", Thesis on "IL-7 and KL", Summary of paper on "IL-7 and KL", Articles written on "IL-7 and KL".