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Paper #001332 :: An Explanation of the Principles and Uses of Supercritical Fluid Chromatography
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A look at the many advantages of this technique, and in what applications it can be used.

Written in 2001; 2,310 words; 3 sources; $ 71.95

From the Paper:

"Although the properties of supercritical fluids were know, it was not until 1958 when Lovelock suggested that a supercritical fluid can be used as a mobile phase in chromatography. Now, supercritical fluid chromatography (SFC) is widely used in extraction, fraction, and chromatography. SFC has many advantages over other chromatography methods. It allows one to separate many substances that cannot be analyzed by gas chromatography. Its applicability is limited by volatility and thermal properties of many organic compounds. Although less volatile compounds can be analyzed by high performance liquid chromatography, very long analysis time and very small column diameters are needed in order to achieve good separations due to the limitations of solute diffusion in the mobile phase. SFC is able to overcome these difficulties and allows high-resolution separation at low temperatures with short analysis times."

Tags: chromatography gas liquid

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