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T- Cell B-Cell Collaborations in the Immune System, 2001.
A descriptive overview of the vertebrate adaptive immune response to both intra and extra-cellular pathogens with explicit focus on T-cell B-cell collaboration and antibody response.
1,425 words (approx. 5.7 pages), 9 sources, APA, $ 47.95
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Abstract
This paper covers the major pathways by which foreign antigens are identified and dealt with through the adaptive immune response which is paramount on B-cell and T-cell responses and interaction with one another in distinct pathways and steps. It includes several diagrams and their explanations of antigens, B-Cells, T-Cells, APC's and more and their interactions and processes they go through.
From the Paper
"All immune responses involving T-cell B-cell collaborations follow distinct pathways of interactions and development. These very pathways of the adaptive immune response are almost entirely dependant on the cellular interaction of B- cells and T- cells with one another. It is within each stage of these pathways and the progression of an adaptive immune response that we will concern ourselves. The following is a condensed synopsis of the adaptive immune response and the cellular interactions that will be the emphasis of this paper. Within secondary lymph tissues foreign antigen is presented to naive B-cells via their surface immunoglobulins (Igs) receptors. The same antigen is also presented to naive T-cells at this time. This presentation and subsequent recognition of antigen by both types of cells results in and end product of proliferation and development of naive B-cells into plasma cells whose function is the production of soluble immunoglobulins (antibodies), and the differentiation and development of memory B-cells whose function is to respond to subsequent exposure to the same antigen. However, this pathway is not self-sufficient and requires the direct interaction of activated T-cells, specifically ?helper? T-cells (Th2 cells) 1,9. It is these T-cells in conjunction with the antigen presenting B-cells that interact to produce a hormonal response to infection. These interactions activate Th2 cells that in turn promote B-cell activation both through T-cell secreted cytokines, (interlukeinI1-2, 4 and 5), and also through direct cell to cell contacts involving specific surface proteins and corresponding receptors and the signaling initiated by the binding of these proteins to one another."
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Stem Cells, 2006.
An overview of the nature of stem cells, stem cell research, and the controversy surrounding the use of stem cells from human embryos.
675 words (approx. 2.7 pages), 3 sources, $ 26.95
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Abstract
The different types of stem cell research involve the use of human eggs - and embryos - as intermediates and are at the center of controversy as to whether it should be considered human life. Recent advances are attempting to produce non-embryonic stem cells as well as address the said issue. This paper discusses the nature of stem cells, what they are, how they are produced and the issues surrounding them.
From the Paper
"Stem cells are undifferentiated cells that have the potential to develop and proliferate into more specialized cells such as neurons or skin cells. These specialized somatic cells comprise the different tissues and organs of the human body. The cloning process currently in use involves the use of the cellular machinery of an egg cell and the genetic material encoded in the nucleus of a somatic cell called somatic cell nuclear transplant (SCNT). First, the egg cell is secured to stabilize it. A needle is inserted into the egg to extract the nucleus and DNA."
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Stem Cells, 2005.
A brief review on the applications of stem cells in human development.
5,166 words (approx. 20.7 pages), 40 sources, APA, $ 129.95
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Abstract
The paper discusses stem cells in human development, a specialized topic in developmental biology, focusing on potential cures for fetal malformations, via stem cell therapies and stem cells characteristics in general. The paper notes that the most promising use of stem cells is their ability to serve as a potential source of replacement cells to treat numerous diseases, such as Parkinson''s disease, Alzheimer's disease, ALS (amyotrophic lateral sclerosis), cancer, and heart disease. The paper further notes that any disease in which there is tissue degeneration can be a potential candidate for stem cell therapies, including spinal cord injury, stroke, burns, heart disease, osteoarthritis, rheumatoid arthritis, muscular dystrophy and liver disease. The paper includes photographs.
Outline:
Abstract
What are Stem Cells?
Types of Stem Cells
Embryonic Germ Layers From Which Differentiated Tissues Develop,
Mechanisms of Action:
Characteristics and Potential Uses
Hematopoietic and Stromal Stem Cell Differentiation
Human Embryonic Germ Cells
Human Adult Stem Cells
Summary of Animal Experiments
Mouse Embryonic Stem Cells
Bovine Embryonic Stem Cells' Studies
Primate Embryonic Stem Cells' Studies
Miscellaneous Animal Studies
Migration of Transplanted Human Cells
Survival of hCNS-derived neurospheres in the ischemic brain.
In Utero Stem Cell Therapy - Stem Cell Transplantation in the Fetus
Ontogeny of Hematopoiesis in Humans
In Utero Stem Cell Therapy in the Mouse
Conclusions
From the Paper
"Embryonic stem cells are difficult to control, as they behave in an unstable manner resulting in unexpected results as they divide, or even cancerous growths. They are indeed more difficult to maintain and expand in culture (Van Blerkom, 1994). ES differ substantially from the stem cells found within the fully developed adult where they can be totally quiescent. Human ES cells may cause an immune reaction when transplanted into people, which means cells used in treatment may be rapidly destroyed unless they are protected by giving medication to suppress the immune system. It appears though that if stem cells were someday to be used for the treatment of disease, there would be greater advantage in using ES cells. "
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Stem Cells, 2002.
This is a persuasive essay on the use of stem cell research and how the cells are derived.
2,155 words (approx. 8.6 pages), 0 sources, MLA, $ 67.95
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Abstract
This paper discusses the controversial issue of stem cell research in the U.S. It conveys the negativity of using human embryos, but also expresses the positive uses of adult stem cells. The author includes remarks made by President George W. Bush, numerous quotes and reference pages and websites.
From the Paper
"The issue of using stem cells (embryonic and adult) is a heated debate among many citizens of the United States. Many people are against all types of research, but do not understand what it is about or what the research can be used for. There are many points that need to be made so people will know that not all stem cell research is harmful, or destroys human life. Embryonic stem cell research can be, and should be avoided, especially when there are other options available to us. Adult stem cell research is an available option that is being used in all parts of the world to find new discoveries. Once society agrees to certain forms of research, scientists may be able to use the research to obtain cures for numerous diseases."
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Stem Cells, 2004.
This paper discusses stem cell research, one of the most truly revolutionary medical science developments.
1,755 words (approx. 7.0 pages), 10 sources, APA, $ 56.95
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Abstract
This paper explains the potential benefits of stem cells result from the fact that they can transform themselves into literally any cell in the body, thus replacing the injured or damaged organs, which will render today's medicines obsolete. The author points out that there are formidable challenges to be overcome; the most serious is the 'ethical' opposition to stem cell research led by pro-life advocates who consider the use of embryos for creating stem cell lines as the killing of potential human beings. This has resulted in restriction of federal funding for stem cell research. The paper states that there are several formidable scientific barriers, such as the tendency of the immune systems to attack transplanted cells, which have to be crossed; therefore, the author believes that stem cell research deserves full support.
Table of Contents
Introduction
Types of Stem Cells
How Are Stem Cell Lines Created?
Sources of Stem Cells for Research Purposes
Fertility Clinics
Aborted Fetuses
Cloning
Made to Order
The Ethics of Stem Cell Research
Arguments Against Stem Cell Research Arguments for Stem Cell Research
Other Ethical Concerns
Issue of Federal Funding
Conclusion
From the Paper
"One of the most dramatic breakthroughs in the history of biological research occurred in November 1998, when two independent teams of American researchers managed to isolate and grow a special kind of human cell called the stem cell. Until then, scientists had struggled long and hard to isolate the elusive cells but capturing them had proved difficult. One reason for this difficulty was that most stem cells only exist in their original form for a short time before turning into the various specialized cells of the body; the other was that the cells need a highly specialized environment to keep them alive outside the body. Other scientists had previously succeeded in culturing stem cells for only short periods; the 'breakthrough' accomplishment was that the pioneering scientists successfully created conditions under which the stem cells could replicate over time without specializing."
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Stem Cells, 2004.
This paper discusses one of the most controversial topics of popular discourse, stem cell research.
2,055 words (approx. 8.2 pages), 3 sources, MLA, $ 64.95
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Abstract
This paper explains that stem cells intended for use in human applications are harvested from humans, umbilical cords, and embryos, and are so valuable because they are master cells with the capability to produce or ?become? any other cell type. The author points out that the reason for the discourse surrounding the topic of stem cells is the fact that the most promising source of stem cells is human fetal tissue; thus, many who hold anti-abortion views find this practice to be highly immoral and repugnant. The paper relates that the problem with umbilical cord stem cells is the small amount that can be harvested from any particular cord; adult stem cells, which pale in comparison to the ability of embryonic cells to differentiate into specialized cells, can be used for research.
From the Paper
"Of course, most people know the origin of human life begins with the sperm fertilizing the egg. After this, a single cell is created that holds all of the genetic information needed to form the entire human body. This cell divides and redivides over several days until these cells (known as totipotent, or as having ?total potential?) begin to specialize into the formation known as the ?blastocyst,? which has a hollow sphere of cells, and a cluster of inner cells (the inner cell mass). While the outer cells of this blastocyst proceed to form the placenta, the cells within the inner cell mass go on to form virtually all of the tissues and organs of the human body. It is these cells that are harvested to research stem cells."
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Stem Cells, 2007.
An overview of stem cells and their potential use to medical science.
1,493 words (approx. 6.0 pages), 6 sources, APA, $ 49.95
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Abstract
This paper examines how scientists believe that stem cell research has the potential to find cures for several previously incurable diseases and how, despite this exciting potential, progress in stem cell research has so far been hampered by serious technical, ethical, and political issues. This paper discusses the types of stem cells and their sources, the potential of stem cell use in medical science, and the issues that are holding back rapid progress in stem cell research.
Outline:
Types of Stem Cell
Sources of Stem Cells
Potential Uses of Stem Cells
Barriers in Stem Cell Research
Conclusion
From the Paper
"Embryonic stem cells are almost always derived from embryos developed from eggs fertilized during fertility treatment in clinics. In the process of in vitro fertilization, eggs removed surgically from a female ovary are fertilized with sperms in a lab for subsequent implant in a woman's uterus. Numerous fertility clinics fuse more than one egg with sperm as a routine in order to try another implant if the first one does not work. Hence, thousands of such "left-over" embryos are stored in liquid nitrogen freezers in the United States and other countries where in vitro clinics exist, which can be used for stem cell research. "
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Stem Cells Research, 2002.
A look at the make-up of stem cells and their use in the medical sphere.
1,883 words (approx. 7.5 pages), 6 sources, MLA, $ 60.95
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Abstract
This paper begins by looking at the properties of stem cells and examines the phenomenon of stem cells, which provide limitless division and the rise of differentiated progeny. It then asks what embryonic stem cells are and looks at how they are cultured in the laboratory. It then discusses adult stem cells and the use of cell therapy today. The paper concludes with expectations for the future.
From the Paper
"Stem cells can be defined as progenitor cells or primitive cells that give rise to other cells. They are totipotent cells also dubbed as the ?master cells? of the body as they contain all the genetic information needed to create all the cells in the body plus the placenta, which nourishes the human embryo. Human cells have this capacity only during the first few divisions of the fertilized egg. Totipotent cells follow a series of stages and become highly specialized after 3-4 divisions. The next stage of division give rise to pluriopotent cells that are highly versatile and can give rise to any cell except the cells in the placenta. At the next stage, cells become multipotent, meaning they can give rise to several other cell types, but those types are limited in number. An example of multipotent cells is hematopoietic cells?blood stem cells that can develop into several types of blood cells, but cannot develop into brain cells. At the end of the long chain of cell divisions that make up the embryo are "terminally differentiated" cells?cells permanently committed to a specific function [Author not known, 2003]."
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Umbilical Cord Stem Cells, 2004.
Examines the ethical and medical issues surrounding the utilizing of stem cells.
5,350 words (approx. 21.4 pages), 18 sources, APA, $ 132.95
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Abstract
Umbilical cord blood offers great hope for the future of stem cell research and use. This paper examines the potential of these types of stem cells in order to demonstrate how stem cells from umbilical cord blood can help scientists solve the ethical debate and provide sick patients with hope for life.
Paper Outline
Introduction
Stem Cell Background
About Umbilical Cord Stem Cells
Umbilical Cord Blood Process
The Great Stem Cell Debate
Conclusion
Works Cited
From the Paper
"Estimations regarding the need for a given cord blood sample vary. One estimate of a child needing his or her own cord blood stem cells is 1:10,000 (Wolf, 2002). Another places the odds at 1:1000 to 1:2000. The probability of use varies depending on individual circumstances. Disturbing statistics reveal that every year there are about 8,000 new cases of cancer in children under the age of 15. These children could potentially benefit from the use of cord blood stem cells, so perhaps expectant parents should make the effort to donate their newborn?s cord blood or store it for their own family?s potential use."
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Hematopoietic Stem Cells, 2009.
A detailed description of stem cells and their use, and risks of use, in different types of transplantation.
4,879 words (approx. 19.5 pages), 54 sources, APA, $ 124.95
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Abstract
This paper defines what are known as stem cells and what is involved in stem cell (SC) transplantation, and provides a list of current uses for SC transplantation. The writer explains that most common sources for such transplants are bone marrow, blood and cord blood stem cells, and describes in detail how bone marrow and cord blood stem cells are obtained and what is entailed in bone marrow transplantation (BMT). Despite considerable progress in BMT over the years, there are still major problems with graft-versus-host disease (GVHD), failure to engraft and lack of suitable donors. The writer notes that younger donors and good transplant timing lead to better transplant outcomes, and suggests that in the future, emphasis should be on better control of GVHD with novel immunosuppressive and other immunomodulatory agents. This paper contains tables.
Outline:
Introduction
Application of SCs in Transplantation
Types of Disorders Treated
Types of SC Transplants Available
Availability & Collection of Different Sources
Bone Marrow Registries
Cord Blood Banks
Donor Search
Growth Factors
Harvesting
PBSC Harvesting
Cord Blood Harvesting
Risks for Donors
Ethical Issues Regarding the Sources
Outcome of SC Transplantation
Factors Affecting the Outcome
Conditioning Regimen
Non-myeloablative Allogeneic HSCT
Time for Engraftment or Immune Reconstitution
Transplant Related Mortality
Relapse
Role of HLA Compatibility
Effect of Other Cells in the Graft in GVHD and GVL, and the Balance of GVHD and GVL
Conclusion
From the Paper
"The sources for allogeneic stem cell transplant include: half-matched family members, unrelated adult volunteer donors, and related or unrelated umbilical cord blood units (CBU) (Burt & Brush, 1999). The ideal allogeneic bone marrow donor for a patient would be a monozygotic twin, since this transplant is not only HLA-matched but also matched for all other genetic loci. A transplant can be done if a related donor with only one HLA difference is identified, although there is a risk of GVHD. For those without siblings or other related donors, unrelated bone marrow donors would be the only option (Carella et al, 2001)."
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Epithelial Cells of the Nephron, 2008.
This paper describes the epithelial cells of the nephron, which is the basic structural and functional unit of the kidney.
1,040 words (approx. 4.2 pages), 11 sources, MLA, $ 36.95
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Abstract
This paper explains that the framework of the nephron in the kidney is made up of epithelial cells. The author points out that there are two types of nephrons, cortical and juxtamedullary, and they are named according to the location within the renal parenchyma. The paper relates that epithelial cells that make up the nephron must be able to preserve nutrients and materials required by the body and return them to circulation, while leaving wastes, toxins and excess water to be expelled. The author states that the epithelia are described by the number of layers and the shape of the cells at the edge closest to the exterior environment, thus helping to prevent bacteria and other foreign materials from entering the body. The paper continues that the epithelial cells of the nephron permit the kidney to have particular functions that include controlling blood pressure.
From the Paper
"Epithelium lines the surfaces of the body and is positioned on the borders between the exterior and interior environments. Epithelium is a tissue composed of cells, bound tightly together with no intercellular connective tissue. These cells derive their food and oxygen from the tissue fluid that filters through from the capillaries in the underlying connective tissue. The epithelium develops in the embryo from all the three germ layers; ectoderm, mesoderm and endoderm. The epithelium is derived from mesenchyme cells that mature into connective tissue, bone, cartilage, blood and the lymphatic system."
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Umbilical Stem Cells, 2007.
This paper looks at the use of umbilical cords as a source for stem cell research.
1,100 words (approx. 4.4 pages), 3 sources, MLA, $ 38.95
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Abstract
In this article the writer notes that stem cells have received much attention because of their unique capacity to renew themselves and morph into several different types of specialized cells. The writer also points out that the practice of harvesting stem cells from aborted fetuses has received much criticism from conservative groups, prompting President Bush to halt federal funding for stem cell research. This paper argues that there is a way to accommodate ethical concerns, while reaping the benefits of stem cell research. The writer maintains that umbilical cords are a viable source of stem cells, and do not raise the same ethical issues as harvesting from fetuses. The writer argues, therefore, that parents should be strongly encouraged to donate their newborns' umbilical cords to public and private banks, to provide scientists with a source of stem cells for their life-saving research.
From the Paper
"Already, umbilical cord stem cells are proving remarkably promising in the treatment of diseases. Researchers have already identified some 67 afflictions that have been successfully treated with cord blood stem cells, and more illnesses are being added to that list. Researchers at the University of North Carolina at Chapel Hill, for example, have released a study regarding the use of cord blood stem cells in the treatment of Krabbe's Disease, a fatal disorder of the central nervous system. Babies born with this hereditary disease suffer seizures, blindness, deafness and feeding problems before death at around age two. However, the researchers found that infusing newborns at birth with the cord blood stem cells from an unrelated donor are still alive well past their second birthday. Though some of the children show problems walking, the majority score normally on cognitive development tests and all the children exhibit normal vision."
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Stem Cells, 2002.
An examination of the ethical debate of whether to use stem cells for research.
1,165 words (approx. 4.7 pages), 8 sources, MLA, $ 40.95
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Abstract
This paper gives a brief description of what stem cells are and how they may be used in scientific research. Recent studies show that stem cells may hold the key to discovering a cure for many mysterious diseases, including Parkinson?s and Alzheimer?s. But the moral issues remain intact, despite the obvious positive consequences. The core of the stem cell debate is a battle over abortion, as stem cells come from embryos. This paper discusses both sides of the debate and looks at government intervention.
From the Paper
"For pro-life advocates, the moral costs of the research far outweigh any potential benefits. For scientists, the possibilities of research are awe-inspiring and bewildering. No one denies the moral dilemma of the stem cell debate. But to turn back now, researchers say, would be like turning our backs on a bright, sustaining light because we are terrified of the shadows it creates. "
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The Use of Fuel Cells as an Energy Alternative, 2002.
A paper which discusses using fuel cells as an alternative to traditional energy sources and their advantages.
1,530 words (approx. 6.1 pages), 10 sources, APA, $ 50.95
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Abstract
The paper shows that fuel cells offer tremendous promise and potential as an energy source. Among topics covered in this paper include: How fuel cells operate, why they are cleaner than a combustion powered engine and the research that is currently being conducted to advance this technology. The paper also lays out the roles the federal government, automakers, and oil companies are playing in investing in fuel technology. It also discusses the problems that need to be overcome in order for the use of fuel cells to meet their full potential as an energy source.
From the Paper
"In summary once the fuel cell market begins to take off, the impact can snowball. Using hydrogen to combine such renewable energy sources with highly efficient fuel cell cars would impact many industries such as the automobile, oil, electricity and natural gas. Furthermore, an added benefit of fuel cell will be the elimination of carbon dioxide that are produced by gas powered engines, instead the only by product produced here would be water. In fact this water will be safe enough to drink because it will be pure. Research will continue to advance the potential of fuel cell as a dependable long term energy source."
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