Abstract This paper begins with a general overview of chemistry to familiarize the reader and describes how chelating ligands form complexes with metal ions. The chelating groups discussed are: Ionophores, British Anti-Lewisite, Cis-dichlorodiammine platinum (II) (Cisplatin?), and Ethylenediaminetetraacetic acid (EDTA). The paper states that Chelation therapy will most likely perfect the removal of tumors without the need for radiation.
From the Paper "Within the periodic table is found the basic building blocks of life. From the organic atoms like carbon (C), hydrogen (H), and oxygen (O) to the in-organics such as sodium (Na), calcium (Ca), and even gold (Au), it has been proven that both are vital to the survival of live. In the mid to late 1800?s, two men by the names of Mendeleev and Lothar Meyer began their work on the reoccurrence of certain characteristics of the known elements of the time (ref 1). It was not until some 15 years later that the periodic table, found in most every chemistry book published today, was accumulated into it's easy to read format by Thomsen and Bohr (ref 1). Since then, many more steps have been made in classifying elements, such as metals, non-metals, and metalloids."
Abstract This paper describes gallium-based chemotherapeutic drugs. Included is a brief discussion of the history and development of these drugs, clinical uses for gallium, and problems with gallium chemotherapy. Also included is a discussion of potential alternate uses for gallium drugs, including using gallium as an antiviral or to combat hypercalcemia.
From the Paper "Gallium is a naturally occurring group IIIa heavy metal. Because of its low melting temperature (303 K), chemists have long used gallium industrially as a component of low-melting alloys. It has only been within the last forty years, however, that scientists have studied gallium in medicine. Following the serendipitous discovery of platinum's antitumor properties in the late 1960s, the U.S. National Cancer Institute started a systematic study of several metallic elements to see if they too might display anticancer effects. While all of the Group IIIa elements (boron, aluminum, gallium, and thallium) displayed significant cytotoxic activity, gallium was the most active and least toxic of these metals when tested against animal tumors.1 Later, in a separate development, researchers noted gallium's ability to localize in bone, leading clinicians to use 67Ga citrate in some diagnostic bone scans. In the 1970s, a physician conducting such a scan observed quite accidentally that gallium accumulated in nonosseous malignant tissue as well.2 Indeed, further tests showed that gallium was the only IIIa metal to display cytotoxic activity when inoculated at a site other than the tumor itself.1 These unique properties spurred a great deal of research interest in developing gallium-based chemotherapeutic agents."
