Abstract
This paper briefly critiques an article by H.X. Wang and T.B. Ng that explores the purification of a low-level molecular mass laccase with HIV-1 reverse transcriptase inhibitory activity from the mushroom Tricholoma giganteum. The paper notes that the study does not appear to have any great over-riding significance and the authors make no effort to acknowledge or isolate factors which might distort the production and activity of ligninolytic enzymes. Finally, the paper asserts that the methodology, besides being couched in opaque language, is not supported by any literature references that this writer can see - save for one. The paper opines that all in all, the reader is left to wonder: what is the point of this study?

From the Paper
"This paper will briefly critique an article by H.X. Wang and T.B. Ng that explores the purification of a low-level molecular mass laccase with HIV-1 reverse transcriptase inhibitory activity from the mushroom Tricholoma giganteum. The paper notes that the study does not appear to have any great over-riding significance and the authors make no effort to acknowledge or isolate factors which might distort the production and activity of ligninolytic enzymes. Finally, the methodology, besides being couched in opaque language, is not supported by any literature references that this writer can see - save for one. All in all, the reader is left to..."

Tags:biochemistry, critique, laccase

Abstract
Sickle cell anemia is a devastatingly painful and fatal disease that strikes those of African-American heritage at a disproportionate rate. After a brief discussion on the generalities of the disease, diagnostics, treatment and prognosis, this paper examines the biochemical and genetic influences of the disease and offers suggestions for further research efforts. Advances in biochemical knowledge and technology are taking research on sickle cell anemia to the next level; however, advances in genetics are even more remarkable. This paper highlights one of the most recent and promising genetic fixes for those afflicted and at risk for sickle cell anemia.

From the Paper
"According to the National Human Genome Research Institute ("Learning About," 2005) sickle cell disease "is the most common inherited blood disorder in the United States." The disease strikes 1:12 African Americans who are parented by two disease carriers who pass on a mutated hemoglobin-Beta gene found on chromosome 11 ("Learning About," 2005). Until recently, sickle cell disease was thought to be a death sentence with most victims not living beyond 20 years of age and the rest generally not living past the age of 50 (Taher & Kazzi, 2005). With new treatments, such as hydroxyurea, victims of the sickle cell genetic mutation are not living past 50 ("Learning About," 2005). After a brief disease profile that includes a discussion of disease pathology, biochemical and genetic influences, diagnostics, treatment and prognosis. Advances in biochemical knowledge and technology are taking research on sickle cell anemia to the next level;"

Tags:sicklecell, biochemistry, genetics

Abstract
In this article the writer discusses prostate cancer. The writer also examines some of the biochemical research that is being carried out to try and determine the causes of this type of cancer. The paper looks at the oxidative stress on cells and the effects of androgen. The writer discusses NSAID-associated gene protein and some of the multi-drug resistance associated proteins.

From the Paper
"Prostate cancer is a disease of aging brought about by changes in cellular biochemistry which result in an imbalance in the pro oxidant-antioxidant balance and in the cellular response to androgen which this brings about. Many advanced cases of prostate cancer become resistant to chemotherapy making the prognosis for those men dismal. It has been shown ... "

Tags:prostate cancer, androgens, prooxidant-antioxidant balance, multidrug resistance associated protein, NSAID- associated gene protein

Abstract
This paper describes lead poisoning, focusing on the chemical processes that take place as lead (II) displaces zinc (II) from ALAD and inhibits hemoglobin synthesis. The technical details of the inorganic and biochemical processes at play are explored and discussed, as well as the mechanisms of various lead poisoning therapeutic strategies. This paper also contains several referenced illustrations and figures.

From the Paper
"The protein ALAD, also know as porphobilinogen, is crucial in heme biosynthesis (2). ALAD, a ZnII metalloenzyme, consists of A and B subunits each of which contain a zinc atom when functional. The functionality of the A and B sites has been determined experimentally by displacement of zinc. When magnesium displaces zinc at the A site ALAD is marginally active. Furthermore, when magnesium replaces the zinc in the B site no change in the activity of the enzyme is observed (3). Thus the A site is key to the activity of the enzyme. However, when PbII displaces the active ZnII ion present in the A- site, the enzyme is rendered useless."

Tags:zinc, hemoglobin, synthesis, alad

Abstract
The paper begins by purifying beef heart and ends with a highly-quantitative analysis of the results of attempting to isolate the enzyme lactate dehydrogenase. It contains every aspect of a detailed biochemistry lab report. The paper contains complex quantitative analysis with supporting statistics. It also has scanned photographs of the gel electrophoresis.

From the Paper
"Lactate dehydrogenase (LDH) is a crucial enzyme that regulates lactate levels throughout the mammalian body. Proper LDH function is essential for a number of important biochemical pathways, including the Cori Cycle and glycolysis among others. Without it, the glycolytic cycle would come to a halt due to diminished nicotinamide adenine dinucleotide (NAD+) reserves, and the buildup of lactate would ultimately result in lactic acidosis-a potentially fatal affliction."

Tags:bovine, centrifugation, chromatography, electrophoresis

Abstract
The drug Lysergic Acid Diethylamide (LSD) and its impact on behaviour and biochemistry has been a topic of exploration in psychology, psychiatry and related fields for decades. Back in 1960, Sidney Cohen in his article "Lysergic Acid Diethylamide: Side Effects and Complications" explored LSD alongside mescaline as a drug "capable of producing transient dissociation states" (p. 30). In fact, in these earlier decades of lessened political correctness and awareness, LSD was used to induce "reversible psychotic-like" states into subjects (ibid). Studies predictably found that "adverse responses" tended to occur when subjects were administered "higher dosage levels (above 47 mcg)" (ibid) though it was considered that "no instance of serious, prolonged and physical side effects were found either in the literature or in the answers to the (subject) questionnaire" (Cohen, 1960, pp. 30-31).

From the Paper
Abstract The present paper aims to explore the relationship between psychosis induced by LSD and psychosis induced by schizophrenia. I propose that traditional studies that use LSD to induce psychosis in normal patients in order to study schizophrenia for pharmacological and other psychological purposes should be abolished, as their biochemical actions are different through the impact on different receptor sites different biochemical actions. Introduction: LSD in Schizophrenic Studies The drug Lysergic Acid Diethylamide (LSD) and its impact on behaviour and

Tags:schizophrenia, lsd, interaction

Abstract
This paper answers two questions for the student that deal with what major he would like to pursue and an impressive part of his character. The paper highlights persistence and the desire to become a pharmacist and uses famous scientists to illustrate the point. The paper employs an overall enthusiastic outlook and conveys a real love for the chosen major and career path.

From the Paper
"Starting with the mechanisms of chemical reactions, I became completely enamored by chemistry. Learning more information and techniques solidified my newfound passion at the time. Later on, I learned about more real-life applications to this science, including biochemistry and pharmacology. As I have realized that this science is intertwined in our daily lives it has inspired me to pursue a major in biochemistry. Through learning biochemistry, I can leverage that knowledge to ultimately pursue pharmacology. My long-term goal is to become a pharmacist. Starting with general chemistry I became curious as to where this new..."

Tags:personal, admissions, biochemistry

From the Paper
"Tay.Sachs Disease


Tay.Sachs disease is one of the few neurodegenerative diseases of known cause (1:419). It results from a lysosomal storage disorder involving a defect in the hexosaminidase enzyme system causing the accumulation of sphingolipids (4:143.147).


The disease was first described by Warren Tay and Bernard Sachs about 100 years ago (3:189). It belongs to a group of diseases..the GM2 gangliosidoses..which, although they result from separate genetic mutations, each of which shares characteristics in common with the others (3:189). One of these characteristics is that all of the diseases are inherited by the autosomal recessive mode of transmission (4:143); another is that each results from a biochemical deficiency in the hydrolysis of GM2 ganglioside cells of the central and peripheral nervous..."

From the Paper
"STEROIDS (ANABOLIC)

Introduction
The popular usage of anabolic steroids makes necessary the study of their effects physically and psychologically. Study results indicate more than minor psychological changes in personality are found with AAS use. These effects can border on dangerousness, with demonstrations of aggressive and violent behavior, and need to be further investigated.

Article Summary
Cooper, Noakes, Dunne, Lambert, and Rochford (1996) studied the prevalence of abnormal personality traits found in chronic users of anabolic-androgenic steroids (AAS). One of the authors became a participant-observer in a group of body builders. The experimental group were twelve body builders using high doses AAS ..."

From the Paper
"Bulimia and Family Systems Therapy
Every year in the United States millions of people suffer from eating disorders. More than 90 percent of those afflicted are adolescent and young adult women (Hoffman, 1994, p. 1).


Approximately 1 percent of adolescent girls develop anorexia nervosa, a condition in which they can literally starve themselves to death, and "eventually half of those with anorexia will develop bulimia" (Hoffman, 1994, p. 4). Bulimia nervosa afflicts 2 percent to 3 percent of young women and involves excessive eating followed by purging the body "of the excess calories by vomiting, abusing laxatives or diuretics, taking enemas, or exercising obsessively. Some use a combination of all these forms of purging" (Hoffman, 1994, p. 3). The third group are binge eaters who engage in episodes of uncontrolled eating without..."