A discussion on peripheral arterial disease, also known as PAD, a chronic condition in which arteries that supply blood to the legs become blocked by a buildup of plaque.
Abstract The following paper examines the symptoms, diagnosis and treatment of PAD, a form of atherosclerosis, a progressive disease characterized by fatty deposits in the inner layer of the arteries, which gradually narrows the artery. The writer particularly focus on 'Raynaud?s' one of the forms of PAD which causes fingers and toes to turn blue and white with cold .
From the Paper \"It's important to remember that many people have PAD without having any symptoms. Such individuals are at higher risk for a stroke or heart attack. Research indicates that the risk for dying from heart disease is six times higher for people who have PAD, and PAD patients have a 30 percent risk of dying from a cardiovascular-related problem within five years after the initial diagnosis of PAD (University of Penn Health System). It is essential that anyone who has health problems or a lifestyle that could lead to PAD be aware of the symptoms of this potentially life-threatening disease, as see a doctor for any problems. Peripheral arterial disease can be controlled in most cases. People only need to be aware of the signs.\"
Abstract The paper discusses the onset of coronary artery disease and the condition of atherosclerosis. The paper explains that coronary artery disease is primarily characterized as an inflammation of the arteries. The paper outlines the causes of this inflammation and examines the strong correlation between coronary artery disease and chronic obstructive pulmonary disease (COPD) as well as with Type II Diabetes. The paper looks at the most serious complication from coronary artery disease, which is the possibility of a heart attack.
From the Paper "Coronary artery disease (CAD) is a frightening name for an all-too common illness. It is the most common type of heart disease and the leading cause of death in the United States for both men and women ("What Is Coronary Artery Disease?" NIH, 2007). More than 64 million Americans suffer from some form of cardiovascular disease, and in 2001, cardiovascular disease was responsible for more than 39 percent of all deaths in the United States (American Heart Association: Heart Disease and Stroke Statistics 2004, cited by "Coronary Artery Disease and Atherosclerosis, Health Concerns, 2006, p1)."
Abstract This paper describes the incidence of coronary heart disease. The author explains coronary artery bypass graft (CABG) surgery. The paper reviews 7 articles on coronary artery bypass graft pain management and applies them to nursing.
From the Paper The average life expectancy of Americans is ... years but almost .... million Americans have one or more types of cardiovascular disease. Among the more common surgical procedures performed among Americans with cardiovascular disease is the coronary artery bypass graft (CABG) at a rate of almost ...., such surgeries taking place annually and an expected ... to ... percent annual increase in the number of CABGs. Consequently, identifying the most effective postoperative comfort measures that ..."
Abstract This paper presents CAD, or coronary artery disease. The paper begins with an overview of CAD, including statistical data. Next, the paper explores the etiology of disease. The paper then examines diagnostic tests used to detect the condition and signs and symptoms of the disease. The paper concludes with a discussion of treatment -- and under-treatment -- of the disease.
From the Paper "Coronary artery disease generally refers to the buildup of cholesterol in the inside layers of the arteries. This buildup slowly narrows the flow of blood through the vessel and the muscles..."
Abstract This paper discusses the Pathophysiology of Coronary Artery Disease (CAD). The paper begins by explaining the processes within the body that result in the signs and symptoms of the disease. The paper also reviews diagnosis and treatment of the disease. The paper focuses on the importance of nursing care and patient teaching for successful rehabilitation of CAD patients.
From the Paper "Plaque on the arteries is a serious physical condition that can be identified before a heart attack or other medical emergency..."
Abstract The paper describes the composition of the circulatory system. The paper explores the common disorders associated with the circulatory system; arterial damage, inflammation and blood clots, hypertension and arterial aneurysms. The paper identifies common procedures and treatment for these disorders. The paper reveals that one of the most pervasive forms of preventative treatment for cardiovascular disease is lifestyle modification, especially a change in diet. The paper details angioplasty, coronary artery bypasses and anti-hypertensives.
Outline:
Make Up of the Circulatory System
Common Disorders Associated with the Circulatory System
Common Procedures and Treatment for the Disorders Identified
From the Paper "The circulatory system, also known as the cardiovascular system, has several functions. These functions include: the transport of substances to and from the cells, maintenance of body temperature, and maintenance of pH as part of homeostasis. The circulatory system of all vertebrates, including humans, is a closed system, meaning the blood is not meant to leave the system. The primary components of the system are the heart, blood and blood vessels ("Circulatory System")."
Abstract This paper examines the current debate among cardiologists and cardiac surgeons regarding the use of coronary artery bypass surgery (CABG) versus drug-eluting stents (DES). The author concludes that the research indicates that, even though cardiac surgeons have conducted many studies that appear to show the benefits of percutaneous coronary interventions (PCI) with accompanying DES, there are still very serious considerations to using these interventions in certain groups of patients, especially those with multivessel coronary artery disease. This paper recommends future research with multicenter trials comparing use of PCI with DES as compared to CABG in terms of both short-term and long-term benefits, mortality rates, revascularization rates and other benefits or complicating factors in order to establish or disavow the superiority of PCI with DES. Thirteen figures are included with the paper.
Table of Contents:
Abstract
Statement of Problem
Key Terms and Definitions
Background of Study
Unprotected Left Main Stenosis
Multivessel Coronary Artery Disease
Summary
Conclusion
Recommendations for Future Research
From the Paper "According to Gunn and Crossman other energy sources are also useful. Sonotherapy, or unltrasound may potential more as a treatment than as a facilitator 'for gene delivery and is 'benign' in its effect on healthy tissue." Photodynamic therapy, or the interacting of photosensitizing drugs, light and tissue oxygen, is under investigation and still only in very early development. Laser energy delivered "via a fine intracoronary wire, is used in a few centers to recanalize block arteries." Gunn and Crossman state that the role of percutaneous clinical "has extended to the point where up to 70% of patients treated have acute coronary syndromes.""
Tags: clinical percutaneous revascularization survival, comorbid conditions, and
Abstract This paper examines how increased heart rates and arterial blood pressure are commonly found following laryngoscopy and endotracheal intubation and how these effects can result in increased danger for coronary-artery disease patients. Through the review of five different articles, it attempts to analyze lidocaine treatment procedures and how effective they are. For each article, a summary is provided as well as a critique of its study strengths. At the end of the paper the similarities and the differences of the articles are compared and contrasted.
From the Paper ""Blood-pressure and pulse-rate responses to endotracheal extubation with and without prior injection of lidocaine" by Bidwal, Bidwal, Rogers, and Stanley (1979).The purpose of this study was to investigate the effects of lidocaine on increased pulse rates and blood pressure following endotracheal extubation during light general anesthesia. Since previous research has pointed out the possible dangers of these increases and it has shown that lidocaine results in depressed cough reflexes under the same conditions, the authors studied prior iv lidocaine administration as compared to without lidocaine in 80 patients undergoing orthopedic, general surgical, and gynecologic operations."
Abstract This paper examines how atherosclerosis is a disease of the arteries that causes it to 'harden' and affects both medium and large arteries. It looks at how it is the principal cause of heart attacks and strokes and how it is responsible for over 50% of all deaths in the western world.
Outline
Introduction
Risk Factors of Atherosclerosis
Pathogenesis of Atherosclerosis
Proliferation of Smooth Muscle Cells
Recruitment of Immune Cells to the Vessel Wall
Adhesion Molecules
Oxidised LDL (oxLDL)
Role of Monocytes/Macrophages
Role of Cytokines, Chemokines and Growth Factors
Foam Cell Formation
Lesions of Atherosclerosis
From the Paper "There are several factors that contribute to the development of atherosclerosis but the prominent risk factor is considered to be hypercholesterolaemia that could be due to genetic defects and/or diet. In relation to the former, it has seen that mutations in the ABCA1 gene are responsible for two genetic disorders, tangier disease and familial hypoalphalipoproteinaemia (FHA) (Medh, 2000). Tangier disease causes cholesterol deposition in macrophages throughout the body due to impairment of cellular efflux and the absence of HDL (Asztalos and Schaefer, 2003). FHA results in decreased cellular cholesterol efflux and degradation of HDL (Brooks-Wilson et al. 1999). Another genetic disorder familial hypercholesterolaemia is a condition that leads to high lipid levels in the plasma due to impaired removal of lipids."
Abstract This paper explains that the heart is a pump responsible for maintaining adequate circulation of oxygenated blood around the vascular network of the body. The author points out that the two main coronary arteries, the left and right coronary arteries, lie in sulci running over the surface of the myocardium, covered over by the epicardium, and have many branches that terminate in arterioles, supplying the vast capillary network of the myocardium. The author believes that, while diseases of this system are common, most of the risk factors are related to lifestyle habits and, thus, are modifiable.
From the Paper "Cardiovascular disease includes dysfunctional conditions of the heart, arteries, and veins that supply oxygen to vital life-sustaining areas of the body like the brain, the heart itself, and other vital organs. If oxygen doesn't arrive the tissue or organ will die. Ischemic heart disease is the term for obstruction of blood flow to the heart. This disorder results because excess fat or plaque deposits narrow the veins that supply oxygenated blood to the heart. Excess buildup of fat or plaque is respectively termed arteriosclerosis and atherosclerosis. Equally significant would be inadequate oxygen flow to the brain, which causes a stroke."
Abstract In this article, the writer looks at the molecular biology of the cholesterol transport from arterial walls to the liver for biliary excretion. The paper looks at all the genes and their agonists and antagonists involved - LXR, PPAR, ABCA1, apoE, oxysterols, cholesterol metabolites etc. The writer then discusses how they all work together to transport cholesterol from the arterial walls in order to minimize atherosclerosis.
From the Paper "Atherosclerosis is a form of arteriosclerosis in which plaque builds up in the inner linings of the arteries. Plaque consists of a combination of fatty substances, cholesterol waste products from cells fibrin and calcium and usually develops in medium and large arteries, thickening their walls and causing them to lose elasticity and so become less resilient. Atheromatous plaques build up in vessel walls and in advanced stages reduce or restrict blood flow through the vessel lumen. The inner covering of the atheroma may ... "
Abstract Discusses arteriosclerosis as the most common problem. Cites inflammatory process and adhesion molecules. Examines the formation of plaques and increased rigidity in the peripheral arteries of diabetics.
From the Paper "Several factors are involved in the narrowing of peripheral blood vessels in diabetics. The most common problem results from atherosclerosis. Atherogenesis begins with the initiation of a lesion in the vessel wall (Ouriel, 2001). In the ensuing ..."
Abstract This paper studies descriptive epidemiology as it relates to the natural history of cardiovascular disease. It begins with an overview of descriptive epidemiology and its application to the heart followed by the presentation of a number of findings from the Bogalusa Heart Study of 1972 through 1997. The paper concludes with a look at new studies and techniques, which are based on the Bogalusa model. Included is the beta-cath system for radiating an artery wall.
Outline
Introduction
Problem Background
Findings
Conclusions and Summary
From the Paper "At its simplest level, Epidemiology can be to have the description of the application of statistical methodologies to analyze the determinants of health and illness of a given population or sub-group within the population. This sort of analysis therefore has an application to the planning and evaluation of interventions and to the causation and prevention of illness. Moreover, as with most sciences Epidemiology presents itself in various formats and although the central role of Epidemiology within a department is to provide valid, reliable and appropriately interpreted data upon which decisions can be based, Epidemiology is usually divided, in a somewhat arbitrary manner along several lines. Our concern here however is with Descriptive Epidemiology as it relates to the epidemiology and natural history of Cardiovascular Disease."
Abstract This paper looks at the use of sildenafil (Viagra) to improve flow-mediated dilatation in the brachial artery. The paper focuses on the effects of this medicinally-induced dilatation on individuals suffering from Type II diabetes. The paper also discusses the effect of Viagra on endothelial cell function, which, in particular, is occluded in diabetes patients. The paper references a recent study on this topic conducted by the University of Tulane Health and Sciences Center.
This paper reviews the qualitative research method used by K.K. Baird and L.L. Pierce as reported in their article 'Adherence to Cardiac Therapy for Men with Coronary Artery Disease' in "Rehabilitation Nursing".
Abstract This paper explains that the purpose of the reviewed study was to find out why these men with coronary artery disease were not taking care of themselves so that new and better ways can be found for these people. The author reports that the qualitative method consisted of one hour interviews with five informants that were involved in a cardiac therapy program. The paper states that the qualitative method is far more appropriate for this type of study than the quantitative method would have been and the researchers used bracketing to shield the data that they collected and analyzed from their own preconceived ideas, which could have greatly affected the results of the study; however, one possible limitations is that the study sample was not large enough.
From the Paper "The way that the subjects for this study were obtained was very appropriate, since they were all older men between 60 and 70 years old that were involved in a cardiac therapy program as a result of CAD. They had all been diagnosed within the past two years, and they were willing participants. The sample size was also adequate. Although the study could have certainly been conducted with more individuals, the fact that there were only five patients interviewed allowed the researchers to have a lot of time with each person. This helped the patients feel that they could actually talk about what they needed and wanted, as well as what they had difficulty with."
