An Overview of Obesity

Paper Summary:

This paper discusses obesity as a complicated and rapidly advancing disease affecting millions of people every year. It analyzes the multiple environmental and genetic factors that may contribute to obesity, as well as patients' risks for co morbid conditions and complications. It discusses the benefits of weight-loss for obese patients.

Table of Contents:
Introduction
Definition
Incidence
Pathophysiology and Epidemiology Obesity
Signs and Symptoms
Anesthesia Management
Conclusions

From the Paper:

"Physiological changes and pharmacokinetic implications exist for obese patients and the anesthesiologist working with them (Casati & Putzu, 2005). Obesity increases fat and lean body mass, with fat tissue increasing at a rate higher than lean body mass, which can affect the distribution of anesthesia based on the lipid solubility of the drug (Casati & Putzu, 2005). Loading doses are often necessary and must be adjusted based on a patient's weight (Casati & Putzu, 2005). Dosages of pharmacokinetic agents are often based on ideal rather than actual total body weight (Casati & Putzu, 2005). Drug dosing is often based overall on the "volume of distribution for the loading dose and on the clearance for maintenance, with volume of distribution being increased if drug is distributed among lean and fat tissues (Casati & Putzu, 2005)."

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