A discussion of current developments in organ transplantation and the importance of the major histocompatibility complex (MHC) in causing transplant rejection.
Written in 2009; 1,708 words; 15 sources; APA; $ 55.95
Paper Summary:
This paper examines the role of the major histocompatibility complex (MHC), B and T cell receptors, cytokines and current developments in the field of transplantation, as well as alternative approaches being tried to induce immunological tolerance. The writer describes MHC and its genes, and its function in presenting an antigenic determinant to the T-cells. The writer explains that cytokines help to mediate immunity, but how their signaling pathways are activated and how they control cell division is not yet clear. Some experimental treatments to prevent rejection of organ transplants, such as pretransplant exposure to donor MHC antigens, are also described. The paper concludes that a better understanding of the mechanisms of rejection and tolerance, and the use of gene therapy, donor bone marrow administration and pretransplant blood transfusion techniques, TLI, and ALG may allow transplantation tolerance in the future.
Outline:
Introduction
Major Histocompatibility Complex (MHC)
T-Cell Receptor (TCR) Molecules
B-cell Antigen Receptor
Cytokine Receptors
MHC in Transplantation
Conclusion
From the Paper:
"The Major Histocompatibility Complex (MHC) comprises a set of molecules present on cell surfaces. This complex is responsible for lymphocyte recognition and antigen presentation. By the recognition of "self" and "non-self", MHC molecules control the immune response, and are therefore, involved in transplantation rejection. Two classes of the MHC are recognized, Class I and Class II MHC molecules, which belong to the Immunoglobulin Supergene Family. T-cell receptors, immunoglobulins, CD4, CD8, and others also belong to this family."
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