Synergistic Actions of IGF-I and Estrogen

Paper Summary:

This paper examines how Insulin-like Growth Factors (IGFs) are mitogens whose functions are important in regulation of cell proliferation, differentiation, and apoptosis, and how estrogen is another hormone that is involved in regulating a large array of cell processes. It looks at how both of these hormones are mitogens that act through receptor-mediated pathways. The MCF-7 cell line is a commonly used, breast cancer-derived cell line because it is easily replicable, and it differs from many others in that estradiol does not induce cell cycle progression. It looks at how recent research has found that synergistic action of Insulin-like Growth Factor-I, its receptor, and estrogen induce cell cycle progression, promote signal transduction of IGF, and, thereby, increase proliferation of MCF-7 cancer cells.

Outline
Introduction
MCF-7 Cell Stimulation
Estrogen
IGF-I and Estrogen Cross Talk
Conclusion

From the Paper:

"While the incidence of breast cancer as well as the recovery rate continues to rise, breast cancer is hardly a new problem. Breast cancer has been around for centuries however some researchers believe we are closer to a cure than ever before. Incidents of breast cancer have been documented back to the early Egyptians when the only treatment was surgical removal of the diseased tissue. Surgery was practiced but it was an extremely radical treatment considering there was no anesthesia available. During the mid 1800's, surgeons first began to keep detailed records of breast cancer. Those statistics indicate that even those treated by mastectomy had a high rate of recurrence within eight years?especially when the glands or lymph nodes were affected."

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