Sotos Syndrome

Paper Summary:

This paper explains the etiology of Sotos syndrome, placing special emphasis on the neurological component of the disorder. The paper also explores the other aspects of the brain that are affected, such as structures involved in memory. In addition, the discussion focuses on the symptoms and the treatment associated with the disorder.

Outline:
Introduction
Sotos Syndrome
Causes
Neurological Components
Psychiatric/behavioral components
Treatment
Discussion and Conclusion

From the Paper:

"As it related to the neurological components of the disorder, the research indicates that Sotos Syndrome is a cephalic disorder or the central nervous system. The syndrome often results in hypotonia which affect mobility and muscle control. The research also indicates that the disorder affects the temporal lobe which in turn has an impact upon memory and hearing. In addition, the discussion focused on the symptoms and the treatment associated with the disorder. The research found a variety of symptoms associated with Sotos syndrome. The most obvious symptoms involve the physical characteristics of people with the disorder. Other symptoms include language delays, hearing loss, aggressiveness, and personality disorders. There appears to be no standard treatment for the disorder but many of the symptoms of the disease can be treated."

Sample of Sources Used:

• Finegan, J. K.,Cole, Trevor R.P.;Kingwell, E.,Smith, M. Lou;Smith, M., ;Sitarenios, G. (November 1994) Language and behavior in children with Sotos syndrome. Journal of the American Academy of Child and Adolescent Psychiatry
• Hoglund, P., Kurotaki N., Kytola S., Miyake N., Somer M., Matsumoto N. (2003)
• Familial Sotos syndrome is caused by a novel 1 bp deletion of the NSD1 gene. J Med Genet 2003; 40:51-54
• NINDS Cephalic Disorders Information Page. Retrieved August 11, 2007 from; http://www.ninds.nih.gov/disorders/cephalic_disorders/cephalic_disorders.htm
• NINDS Hypotonia Information Page. Retrieved August 11, 2007 from; http://www.ninds.nih.gov/disorders/hypotonia/hypotonia.htm

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