Psychopharmacologic Drug SSRI

Paper Summary:

This paper explains that antidepressants are a group of psychoactive medications that alleviate the signs and symptoms of mood disorders with a pre-dominantly depressive mood. The paper then explains that an understanding of the major mechanisms of action of these drugs can be best accomplished through understanding the pathogenesis of mood disorders. The paper then relates that, by understanding the mechanism of SSRI (e.g. venflaxine), it is possible theoretically to infer the neurobiological component of the pathogenesis of increased suicidality in depressed adolescents.

From the Paper:

"The psychopharmacologic effectiveness of anti-depressants center around one of three mechanisms of action: increasing serotonin and norepinephrine levels through blocking of presynaptic 5-HT and norepinephrine receptors (i.e. interruption of negative feedback for neurotransmitter regulation), blocking of serotonin or norepinephrine reuptake by the presynaptic neuron or inhibition of MAO to interrupt deactivation of these neurotransmitters (Bhalla & Aronson). Selective serotonin reuptake inhibitors (SSRIs) will be discussed in further detail."

Sample of Sources Used:

• Bhalla, Ravinder N & Sarah C Aronson. "Depression." eMedicine.com. 2006. 14 Aug 2007. <http://www.emedicine.com/med/topic532.htm>.
• Leslie Laurel K, et al. "The Food and Drug Administration's Deliberations on Antidepressant Use in Pediatric Patients. Pediatrics. 116.1 (2005): 195-204. 14 Aug 2007. <http://pediatrics.aappublications.org/cgi/content/full/116/1/195>.
• March, John, et al. "Fluoxetine, Cognitive-Behavioral Therapy, and their Combination for Adolescents with Depression: Treatment for Adolescents with Depression Study (TADS) Randomized Controlled Trial." JAMA. 292 (2004): 807 -820. 14 Aug 2007. <http://jama.ama-assn.org/cgi/content/full/292/7/807>.

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