Nitric Oxide (NO)

Paper Summary:

This paper explains that nitric oxide is an endothelium-derived relaxing factor, a neurotransmitter and an euro modulator present in the central and peripheral nervous systems. When generated in surplus, a likely toxic molecule forms part of the resistance against diseases. The author points out that the primary problem involved in the detection of NO result from its short span of life and a very low rate of concentration. Nonetheless, the paper demonstrates several quantitative modes for measuring NO and indicates their limitations. The paper stresses that the endothelium performs a vital role in the determination of blood pressure; primary endothelial irregularities, in addition to irregularities secondarily influencing the endothelium, are all possible suppliers to the advances of hypertension. Many charts and graphs.

Table of Contents
Introduction
Nitric Oxide: Advantages and Disadvantages
Is Nitric Oxide the Same Substance as Endothelium Derived Relaxing Factor
Nitric Oxide's Interactions with the Vascular Endothelium
Ways Nitric Oxide is Measured and the Problems Associated with Measuring
Conclusion

From the Paper:

"The hydrogen peroxide has been projected to be a freely diffusible EDHF as agonist evoked relaxation in some arteries that are NO and autonomous prostanoid are inhibited by the enzyme catalyse that destroys this reactive oxygen species. Such findings have not been general and hence the role of hydrogen peroxide in EDHF responses is evoked by gap junction dependent and independent mechanisms. It is seen earlier that EDHF-type relaxations evoked by acetylcholine, ATP, substance P and cyclopiazonic acid depend on gap junctional communication. But the calcium ionophore A23187 irrespective of evoking EDHF-type relaxations was not vulnerable to gap junction inhibitors. Incubation with catalyse resulted in marked attenuation of A23187 induced EDHF-type relaxations but only inhibited reactions induced by high concentrations of acetylcholine. This indicated that EDHF-type relaxations induced A23187 may be arbitrated by hydrogen peroxide and would not associate with gap junctions."

More papers on Nitric Oxide (NO):

• Descriptive Essay # 8022 : "Hemoglobin, Oxygen Transport and Nitric Oxide"
• Research Paper # 91468 : "Asthma and Nitric Oxide"
• Research Paper # 8091 : "The Nose is Smart: Nitric Oxide Dynamics in the Airway"

APA Citation:

MLA Citation: