Neurotransmitter Transporters

Paper Summary:

This paper identifies two kinds of neurotransmitter transporters: Vesicular transporters that package transmitters into synaptic vesicles; and plasma membrane transporters that remove transmitters that have been released and then recycle them. The paper focuses on the present research status of both vesicular and membrane transporters. Special attention is paid to their anatomical and cellular localization, pharmacological properties and involvement in the physiology of the normal and pathological neural system.
Outline
Abstract
Introduction
Transporters in Vesicle Cycle
Vesicular Transporters(VNTs)
Plasma Membrane Transporters
Related Diseases
Summary

From the Paper:

"Neuron is a highly specific cell for its important function, which served as intercellular communication. Nerve cells communicate with each other and with target cells by transmitting electrical signals and by releasing neurotransmitter. At a chemical synapse that releases neurotransmitter, the presynaptic and postsynaptic cells are separated by the synaptic cleft, then neurotransmitter will naturally be the agent to contact both sides. The information neurotransmitter past on depends on the nature and strength of specific neurotransmitter and different target receptors at the postsynaptic cell. This complex procedure is vital to an organism; actually, they not only affect basic functions such as the coordination of muscles and the endocrine system, but also cognitive functions such as learning and memory. Additionally, almost all neural system diseases are highly concerned with neurotransmitter, so as to transporters. The study of transporter in anatomical and cellular localization, pharmacological properties, and involvement in the physiology of the normal/pathological neural system is necessarily to be part of neural disease research."

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