NF-kB and Akirin Proteins

Paper Summary:

The paper provides a review of the relevant literature to determine what current scientific researchers have found concerning Akirins and what future potential this nuclear factor holds for improving the human condition. The paper provides an analysis and critique of a series of recent articles concerning the transcription factor NF- B and Akirins. The paper concludes that the identification of the Akirin proteins will further accelerate immunological research and this may well be the last generation to die a natural death and suffer the ravages of cancers and HIV/AIDS.

Outline:
Statement of Topic Significance
Overview of Literature Review
Review and Analysis
Summary of Findings

From the Paper:

"Genetic engineering and experimentation hold enormous promise for eradicating many of the diseases that currently plague mankind, and researchers may even be able extend the human lifespan to unprecedented levels in the future. More importantly, perhaps, ongoing research into the human innate immune systems also suggests that such increased lifespans will be healthier and devoid of many of the physical and cognitive problems that currently go hand in hand with the aging process. In the tradition of "standing on the shoulders of giants," scientists today continue to expanding the ever-growing body of knowledge using newly discovered methods and tools that promise to yield these important research outcomes and one such tool has been the recent discovery of protein, which has been termed "Akirin.""

Sample of Sources Used:

• Beutler, B. & Moresco, E. M. (2008, January). Akirins versus infection. Nature Immunology, 9(1), 7-9.
• Goto, A., et al. (2008). Akirins are highly conserved nuclear proteins required for NF-B- dependent gene expression in Drosophila and mice. Nature Immunology, 9, 97-104 in Tufet and others.
• Gough, N. R. (2008, January 8). Akirins clarify NF-B signaling. Scientific Signaling, 1(1), 6.
• Hayden, M. S. & Ghosh, S. (2008, February). Shared principles in NF- B signaling. Cell, 132, 344-362.
• Tufet, M. (2008). Innate immunity: NF-B is not alone. University of California at San Diego. [Online]. Available: http://www.signaling-gateway.org/update/updates/200802/ nri2259.html.

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