Lysergic Acid Diethylamide

Paper Summary:

The paper examines the effects of lysergic acid diethylamide (LSD) on the central nervous system and focuses on the body of research about the link between its interaction with serotonin receptors and the onset of hallucinations. The paper discusses how although one receptor in particular is believed to be the key, the lack of research on the subject in general precludes a definitive determination at this time.

From the Paper:

"Lysergic acid diethylamide (LSD) causes hallucinations and detachment from reality. Since neuro psychiatric disorders such as schizophrenia present very similar symptoms, these profound if episodic perceptual distortions can be viewed as symptoms of temporary damage to the Central Nervous System. Serotonin receptor activation has long been thought be directly affected by LSD, yet after 30 plus years of research, the precise mechanism by which LSD bonds with which of several serotonin receptors, remains a matter of conjecture."

Sample of Sources Used:

• Abraham, H., & Aldridge, A. (1993). Adverse consequences of lysergic acid diethylamide. Addiction, 88(10), 1327- 1334. Retrieved Saturday, March 10, 2007 from the Academic Search Premier database.
• Egan, C., Herrick-Davis, K., Miller, K., Glennon, R.& Tilter, M. (1998) Agonist activity of LSD and lisuride at cloned 5HT[sub 2A] and 5HT[sub 2C] receptors. Psychopharmacology Vol. 136 Issue 4, p409- 415.
• Gresch, P., Strickland, L.& Sanders-Bush, E. (2002). Lysergic acid diethylamide-induced Fos expression in rat brain: role of serotonin-2A receptors. Neuroscience, Vol. 114 Issue 3, p707.
• Gresch, P., Smith, R., Barrett, R. & Sanders-Bush, E. (2005) Behavioral Tolerance to Lysergic Acid Diethylamide is Associated with Reduced Serotonin-2A Receptor Signaling in Rat Cortex. Neuropsychopharmacology, Vol. 30 Issue 9, p1693- 1702.
• Haigler, H.J and Aghajanian, G.K. (1974). Lysergic Acid Diethylamide And Serotonin: A Comparison Of Effects On Serotonergic Neurons And Neurons Receiving A Serotonergic Input. Journal of Pharmacology And Experimental Therapeutics, Vol. 188, Issue 3, 688-699.

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