Knockout Mice Experiments

Paper Summary:

This paper provides a review of the literature to determine the mechanisms and techniques of the knockout mice experiments, including how they are performed and how they affect the mice at the cellular level in terms of cell structure and/or function. The paper discusses some of the experiments in which knockout mice have been used in the study of diabetes. The paper concludes that having large numbers of knockout mice available for the screening of potential drugs will accelerate the discovery of new types of medications and the understanding of the etiology of a number of diseases, including diabetes.

Outline:
Introduction
Review and Discussion
Conclusion

From the Paper:

"One of the unfortunate consequences of living in the 21st century is the fact that people today stand a better chance of contracting diabetes than ever before. In fact, over the past few decades, the incidence of diabetes has approached epidemic levels and there are currently 177 million persons with diabetes in the world (World Health Organization 2005). The basis for this increased incidence of diabetes has been directly correlated with many aspects of modern lifestyles, particularly a paucity of exercise combine wit an unhealthy diet characterized by fast food and vending machine snacks (Alonso-Magdalena et al. 106)."

Sample of Sources Used:

• Alonso-Magdalena, Paloma, Sumiko Morimoto, Cristina Ripoll, Esther Fuentes and Angel Nadal. (2006). "The Estrogenic Effect of Bisphenol a Disrupts Pancreatic [Beta]-Cell Function in Vivo and Induces Insulin Resistance." Environmental Health Perspectives 114(1):106.
• Barondes, Samuel H. Better Than Prozac: Creating the Next Generation of Psychiatric Drugs. New York: Oxford University Press, 2003.
• Bertazzi, P. A., D. Consonni, S. Bachetti et al. (2001). "Health effects of dioxin exposure: a 20- year mortality study." American Journal of Epidemiology 153:1031-1044 in Alonso- Magdalena et al. at 107.
• Bowers, Barbara J. (2000). "Applications of Transgenic and Knockout Mice in Alcohol Research." Alcohol Research & Health 24(3):175.
• "Briton Wins Nobel Prize for His 'Knockout Mice.'" (2007, October 8). The Evening Standard (London):4.

More papers on Knockout Mice Experiments:

• Descriptive Essay # 132084 : "Transgenic Mice"
• Analytical Essay # 129555 : "June Wayne's "Knockout"
• Research Paper # 101967 : "Epigenetic Mechanisms in Genetically Modified Mice"

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