Paper Summary:

The paper is written in NIH standard format style. It details a completely novel, potential experiment in determining prion protein pathogenesis by use of the Golgi. The paper outlines the specific aims, the materials and methods, expectations, and future work in a logical order. The purpose of this research is to determine whether or not the Golgi Apparatus is instrumental in facilitating the distribution of infectious prion proteins from infected neurons. It is hypothesized that constitutive exocytosis from the Trans end of the Golgi Apparatus is a vector through which infectious prions exit an infected neuron. It is also hypothesized that chemical inhibition of exocytosis may decrease formation of pathogenic PrPSc from healthy PrPc.
The paper includes figures.

From the Paper:

"Steps toward understanding the nature of these dreaded pathogens are extremely important. Many lives may depend on the development of a treatment, since it is unknown how many people may be carrying PrPSc. The death inflicted by prion illnesses is a slow, excruciating, unimaginably frightening ordeal. In addition, infectious prions are extremely resilient, able to withstand temperatures that carbonize meat, sterilizing doses of UV radiation, and standard autoclaving (4). The pathogenic PrPSc protein poses health risks to not only those who consume and work with beef, but also to physicians, nurses, and technicians who may be exposed to potentially-contaminated neurological tissue."

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