Factor Five Van Leiden Disorder

Paper Summary:

This paper examines how Factor Five Van Leidenis, also known as Factor V Leiden Thrombophilia, is a disorder that is characterized by a poor anticoagulant response to the APC or the so called 'activated protein C'. It looks at how it is most likely to occur in women with a history of venous thromboembolism during pregnancy, or in association with a high usage of oral contraceptives or in cases where members of one's family have suffered from venous thromboembolism.

From the Paper:

"It is also as yet unknown whether the prophylactic treatment of asymptomatic carriers or of carriers with a previous obstetric history is effective or not. This means that those patients with or even without a coagulopathy who may develop an acute thromboembolism during the term of their pregnancy would require a complete and full anticoagulation with intravenous unfractionated heparin, for five to ten days. Therefore, an intravenous dosage of intravenous anticoagulation of heparin, which is followed by a continuous infusion, is recommended for these pregnant women at high risk due to Factor V van Leiden disorder."

Sample of Sources Used:

• Bloomenthal, Dena; Dadelszen, Peter von; Liston, Robert; Magee, Laura; Tsang, Peter. (July 9, 2002) "The effect of Factor V Leiden carriage on maternal and fetal health" Canadian Medical Association Journal. Vol: 167; No: 1; pp: 38-41
• "Clinical Utility" Retrieved From http://www.cdc.gov/genomics/activities/files/print/VTE_ClinicalUtility.pdf Accessed 12 February, 2006
• "Haemostatic Disorders, Non-platelet" Retrieved From http://www.emedicine.com/med/topic3555.htm Accessed 12 February, 2006
• Kujovich, Jody L. (14 May, 1999) "Factor V Leiden Thrombophilia" Retrieved From http://www.geneclinics.org/profiles/factor-v-leiden/details.html Accessed 12 February, 2006
• Meinardi, Johan R; Middeldorp, Saskia; de Kam, Pieter J; Koopman, Maria M. W; van Pampus, Elisabeth C. M; Hamulyak, Karly; Prins, Martin H; Buller, Harry R; der Meer, Jan van. (March, 2002) "The Incidence of recurrent thromboembolism in carriers of factor V Leiden is related to concomitant thrombophilic disorders" British Journal of Haematology. Vol: 116; p. 625.

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