Drugs Against Malaria

Paper Summary:

The purpose of this research paper is to explore the application of drugs against malaria to assess their efficacy and determine whether it is possible to eradicate malaria in some of the most affected regions of the world. The primary research questions presented to assess this are as follows: (1) What direction should current drug therapies take to eradicate malaria, in light of new, drug resistant forms of the disease? (2) Are genetically modified mosquitoes a more plausible alternative to drug therapy or vaccines? (3) Would use of genetically modified mosquitoes present more problems by changing the environment or inciting confusion and antagonism among populations in which these mosquitoes are released? To answer these questions, the paper proposes a quantitative meta-analysis of the literature currently available comparing past and present drug therapies and research with new focus on the use of transgenic mosquitoes to combat malaria compared with recent drug therapies.

Outline:
Introduction
Background to Problem
Purpose
Significance of Study
Preliminary Literature Review
Method
Limitations

From the Paper:

"Malaria has a long biological history as a member of the "protozoan members of the Plasmodium genus" which causes malaria when humans are injected by the bite of a mosquito carrier (Kiple 682). Since early times human beings have developed some immune response allowing them to resist some of the more serious forms of the disease, especially in areas including tropical Africa remain "plagued with malaria" more so than other places in the world (Kiple 682). Despite this, malaria still infects millions of people and recently realized a resurgence of power. Typically agents or drugs used to combat malaria directly attacked the parasite or vector, however newer studies suggests that a complex interaction of multiple factors including the interaction "between parasite, vector, host and environment" (Tenenbaum 760). "

Sample of Sources Used:

• Dimatteo, R. & Rosenthal, R. Meta-Analysis: Recent developments in quantitative methods for literature reviews. Annual Review of Psychology, (2001): 59.
• Enserink, M. Ecologists see flaws in transgenic mosquito. Science, 297.5578(2002): 30-31.
• Kiple, K.F. Malaria: Poverty, race and public health in the United States. Journal of Southern History, 69.3 (2003): 682.
• Long, C.A. & Hoffman, S.L. Parasitology. Malaria from infants to genomics to vaccines. Science, 297.5580 (2002): 345-357.
• Tenenbaum, D.J. Breakthroughs put the bite on malaria. Environmental Health Perspectives, 110.12 (2002): 760.

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