Diet and Neurogenesis

Research Paper # 26505

Biology > Molecular and Cell
Medical and Health
Medical and Health > Nutrition and Exercise

A look at the effect of a dietary restriction regimen on neurogenesis and neuronal protection.

3,269 words () | 5 sources | MLA | 2003 United States

Paper Summary:

For many years nutritionists advised the general public about the cardiovascular implications of maintaining a diet regimen that restricts calorie intake. Information has now surfaced that a dietary restriction (DR) regimen has neurogenic implications. A DR regimen involves calorie restriction or intermittent fasting with maintained vitamin and mineral intake. This paper focuses on the effects of a DR regimen on neurogenesis and neuroprotection in the hippocampus and dentate gyrus. The contributory effect of brain derived neurotrophic factor (BDNF) on neurogenesis is also examined in conjunction with a DR regimen.

From the Paper:

"Further study in this field of neuroprotection involves establishing how the cellular stress induced by DR and the subsequent production of BDNF is able to increase the resistance of hippocampal neurons (2). In addition, it would be important for researchers to find applications of this neuroprotection in neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease. Neurodegenerative disorders have been characterized as involving increased oxidative and metabolic stress, and overactivation of glutamate receptors (2). If DR results in the production of BDNF, which has been found to increase neuronal resistance, then the next logical progression of this research involves their use with neurodegenerative disorders."