A discussion on the current concepts and mechanisms in the pathogenesis of atherosclerosis.
Written in 2006; 1,977 words; 7 sources; MLA; $ 62.95
Paper Summary:
The paper identifies atherosclerosis as an inflammatory disease and discusses the causes and the manner in which it occurs. The paper gives a well documented and technical explanation of the processes involved and includes diagrams.
Outline:
Introduction
Immune Cells involved in the Lesions of Atherosclerosis
Immune Cells Patrol to the Vessel Wall
Chemotactic Transmigration
The Role of Macrophages in Atherosclerosis
T-Cell Types and Function in Atherosclerosis
CD8 Cells and T Cells Involved
Summary
From the Paper:
"Macrophages (MPh) and T cells are generally common components found in atherosclerotic lesions, thay may also contain a few mast cells and the occasional B cell. T cells are activated by the antigens locally presented by antigen-presenting macrophages and dendritic cells. Activation inspires a production of interferon- (IFNg), which not only primes the macrophages for activation but also regulates the smooth muscle and endothelial functions. Activated macrophages produce pro-inflammatory cytokines such as tumour necrosis factor- (TNFa) and IL-1, which can induce pro-coagulant (Coag), fibrinolytic (fibr.), and adhesive properties on endothelial cells (EC)."
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