An analysis of the factors that contribute to successful and unsuccessful wound healing.
Written in 2003; 1,107 words; 4 sources; MLA; $ 38.95
Paper Summary:
This paper examines how wounds and their subsequent repair are a process that occurs without complication in the majority of individuals throughout the course of their lives. It shows how there are a number of processes involved in the healing of a wound which include clot formation, inflammation, granulation formation, proliferation and remodeling. It covers the series of events that occur during the natural healing of an open wound in molecular detail and attempts to explain why some wounds do not heal well.
From the Paper:
"Wounds and their subsequent repair are a process that occurs without complication in the majority of individuals throughout the course of their lives. Initially, a thrombus is formed by the activation of platelets. This is followed by an inflammatory phase that involves the influx of members of the innate immune system such as PMN and macrophages. The macrophage plays an important role by orchestrating these events, and releasing FGF to cause the formation of granulation tissue in the proliferative phase. Here, fibroblasts lay down collagen and extracellular matrix as well as aiding angiogenesis. The wound can then close due to the proliferation of keratinocytes. The resultant scar can then be remodelled over the following months. Infection and disease can inhibit this process."
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