Vitamin B12 Model Compounds

From the Paper:

"Three derivatives of cobaloximes 1 containing substituted alkyl groups linked to the cobalt atom were prepared. Cobaloximes are cobalt(III) complexes in which two dimethylgloxime anions chelate the metal and form hydrogen bonds to each other1. This results in a planar tetrahedral group surrounding the cobalt with two axial groups. One axial group is the base pyridine and the second axial group is an alkyl group. In this reaction the pH of the solution determined which derivative was prepared. The oxidative addition of the acrylonitrile ligand 2 to the reduced cobaloximes in neutral solution produced the alpha derivative. In basic solution the beta derivative was formed. The third derivative was formed with the deprotonation of the beta derivative, which then underwent oxidative addition to form the trans derivative. The spectra of the cobaloximes derivatives were recorded using infrared and 1H NMR. The spectra were in agreement with the proposed structures of the derivatives."

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