Trans Fatty Acids: A Death Sentence

Paper Summary:

This paper examines how trans-fatty acids (TFAs) are lipids that have been chemically manipulated to become more solid at room temperature. In particular, it looks at how they are broken down by the body and how they can be a cause of heart disease.

From the Paper:

"Dietary fatty acids are emulsified by bile acids in the small intestine and transformed into chylomicrons which enter the bloodstream via the lymphatic system. Fatty acids are also taken up by cells, where they may serve as fuels for energy production. Chylomicrons can have two outcomes depending upon the body's need for energy, either being stored or oxidized. The oxidation of fatty acids produces acetyl-ScoA, which is the platform for cholesterol synthesis. Excess cholesterol can be stored or deposited on the walls of arteries, narrowing them. The stored fatty acids, as triacylglycerol (triglyceride) in white adipose tissue, also results in the formation of acetyl-ScoA, but through a different pathway."

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