The Role of Proteins in Mitosis

Paper Summary:

This paper describes the model that was used to study the role of microtubule-associated proteins in mitosis. The paper explains that microtubules play a significant role in a number of cellular processes, including mitosis, cell motility, and intracellular vesicle transport. It also points out that the dynamic behavior of microtubules plays a significant part both in cell cycle actions and in cell segregation.

From the Paper:

"Kinesins and dyneins play significant roles throughout cell dissection. By means of RNA intrusion (RNAi) to reduce individual or groupings of motors along with immunofluorescence and time-lapse microscopy, the mitotic roles of cytoplasmic dynein and all 25 kinesins in Drosophila S2 cells are examined. It is shown that four kinesins are concerned in bipolar spindle assembly, four kinesins are involved in metaphase chromosome alignment, dynein plays a role in the metaphase-to-anaphase transition, and one kinesin is needed for cytokinesis. efficient redundancy and alternative pathways for completing mitosis were observed for many single RNAi knockdowns, and failure to complete mitosis was observed for only three kinesins. As an example, inhibition of two microtubule-depolymerizing kinesins originally formed monopolar spindles with unusually long microtubules, but cells ultimately formed bipolar spindles by an acentrosomal pole-focusing mechanism. From our phenotypic data, we construct a model for the distinct roles of molecular motors during mitosis in a single metazoan cell kind. ."

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