The Aging Brain and Disease

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"One of the ironies of growing older is that just as one begins to acquire wisdom, senility may also be setting in. Most experts seem to agree that many of us will experience noticeable mental decline by age 65. After age 50 some important areas of the brain lose considerable numbers of neurons (Selkoe, 1992). But it is not clear how such alterations in size and density relate to mental function, or whether these or other organic shifts influence the rate of cognitive decline. However, by the age of 65-74, 3% of the population have some cognitive impairment and by 85, nearly half may be demented (Hachinski, 1992).

Some of the more specific , non-disease, changes in the brain have been studied and summarized by Selkoe (1992). He states that structural and chemical modifications that typify the aging brain become apparent in late middle life, in the 50s and ..."

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