Stem Cells, the Micro-environment and Cancer

Paper Summary:

This paper describes the recent advances in the understanding of intra- and extracellular factors in tumor proliferation. A rapidly expanding aspect with regard to tumor pathogenesis is the micro-environment created by the tumor. Several factors that inhibit lymphocyte activation and proliferation are discussed. Future oncological treatment as an application of these new findings suggests a tumor-specific, multi-targeted approach should be adapted.

From the Paper:

"In recent years, many factors in the proliferation of cancer cells has advanced to the point that more questions are being raised than answered. One of these is that several micro-environmental factors are observed to be playing a more active role in oncogenesis. This goes without saying that the most prevalent cancer-related mortalities then and now continue to be lung, breast, colon and prostate cancer. This leads to the question of whether or not present inquiries and treatments comprehend the ever-expanding list of intra- and extracellular mechanisms at work in tumor cell environments. Micro-environments serve to provide cells in general a physiologically neutral, nutrient-rich environment along with stable extracellular support. "

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