Searching for New Antifungal Antibiotics

Paper Summary:

The paper discusses the necessity to research new antibiotics and other compounds with biological activities because of bacterial resistance. The paper then lists various infections, their treatment and their mobility as well as discusses methods of genetic manipulation of marine cultures in the search for newer antibiotics. The paper also investigates. In addition, the paper looks at the group of bacteria belonging to the genus Streptomyces, which has great antibiotic properties.

Outline:
Resistance to Antibiotics
Fungal Infections and Antifungal Antibiotics
Antibiotics produced by Streptomyces
Conclusion

From the Paper:

"(Gupte, et al., 2002). Healthy individuals are prone to a host of superficial infections such as Athletes foot and nail infections, and in rare occasions, systemic infections that are life-threatening such as histoplasmosis (Barrett, 2002). However, debilitated or immunocompromised individuals such as AIDS patients, transplant recipients and cancer patients are susceptible to a large number of opportunistic systemic fungal infections. This is due to the inability of the patient's immune response to fight normally benign fungi. Other individuals infected have been those subjected to invasive medical procedures such as the use of prosthetic devices and vascular catheters and extensive surgery (Georgopapadakou and Walsh, 1994, 1996). Fungal infections from these susceptible patients are quite often difficult to diagnose and treat and this leads to high mortality rate. "

Sample of Sources Used:

• Barrett, D. (2002). From natural products to clinically useful antifungals. Biochimica Et Biophysica Acta-Molecular Basis of Disease, 1587: 224-233.
• Gallis H. A., Drew R. H., Pickard W.W. (1990). Amphotericin B: 30 years of clinical experience. Reviews of Infectious Diseases, 12: 308-29.
• Georgopapadakou, N. H. and Walsh, T. J. (1994). Human mycoses: drugs and targets for emerging pathogens. Science, 264: 371-373.
• Georgopapadakou, N. H. and Walsh, T. J. (1996). Antifungal agents: chemotherapeutic targets and immunologic strategies. Antimicrobial Agents and Chamotherapy, 40: 279-291.
• Ghannoum, M. A. and Rice, L. B. (1999). Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clinical Microbiology Reviews, 12: 501-517.

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