Phenytoin

Paper Summary:

Discovered in 1938, phenytoin is an antiepileptic prescription drug used primarily to control seizures (convulsions) in certain types of epilepsy. Its range of clinical use is broad and some have dubbed phenytoin's wide parameters as remarkable. This paper shows that before arriving at any conclusion, however, it is imperative that one analyzes the known facts surrounding this drug and its versatile capabilities.

From the Paper:

"One of the best ways to avoid such reactions is to use caution by becoming aware of one's medical condition and history. The liver is the chief site of biotransformation of phenytoin; patients with impaired liver function, elderly patients, or those gravely ill may show early signs of toxicity. A small percentage of individuals who have been treated with phenytoin have been shown to metabolize the drug slowly. Slow metabolism may be due to limited enzyme availability and lack of induction; it may be genetically determined."

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