Nucleoside Analogues

Paper Summary:

This paper discusses nucleoside analogues as used in chemotherapy and antiviral therapy. The different types of nucleotide analogues are outlined by structure. The transportation of these drugs across the lipid membrane, intracellular metabolism (activation) and mechanism of action are also discussed. The last portion discusses anti-retro viral and chemotherapeutic uses of some agents as outlined above, resistance and counter-resistance factors.

From the Paper:

"Structure and different groups of nucleoside analogues. Nucleoside analogues are synthetic drugs that mimic certain nucleosides found intracellularly, specifically the cell nucleus and mitochondria. These drugs are mostly used in oncologic therapy as well as antiviral therapy. Their general mechanism of action relies on their ability to insinuate themselves into replicating strands of DNA or transcribed RNA, taking the place of the nucleoside they are derived from. This has the effect of halting DNA or RNA synthesis, halting viral replication and in some cases, triggering apoptosis. In either case, this consequently results in slowing down and stopping tumor cell or viral replication."

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