IL-7 and KL

Paper Summary:

IL-7 and KL are stroma-derived cytokines, both of which are necessary for the proliferation, survival and differentiation of thymocytes. This paper show that the loss of intrathymic IL-7 production may underlie various forms of acquired immunodeficiencies, such as those occurring after BMT, HIV infection or during aging. The paper concludes that data indicates that the CD45- HLA-DRdim TEC are the only intrathymic source of IL-7 and KL in the human thymus. These cells are present in both the cortex and medulla of the thymus and direct infection of the TEC is not a mechanism for impaired thymopoiesis in active HIV infection.

Table of Contents:

Abstract
Introduction
Study Design
FACS Analyses
RT-PCR
Immunostaining
HIV Challenge and Analysis
Results and Discussion
Acknowledgments
References

From the Paper:

"KL exists in both membrane-bound and secreted isoforms, which result from differential splicing. Inclusion of the 6th exon results in a transcript encoding the transmembrane domain of the membrane-bound form.
RT-PCR primers designed to detect each KL isoform as different sized products demonstrated the presence of both transcripts in the CD45- HLA-DRdim populations, but no other sorted populations of thymic cells.11 Since thymocytes express both the IL-7 receptor and c-kit, the expression of both IL-7 and KL by the same TEC infers that the thymocytes are stimulated simultaneously through the IL-7R and c-kit interaction."

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