Herpes Simplex Type 2 and Immunobiology

Paper Summary:

This paper explains the symptoms of the Herpes simplex type 2 virus, as well as how the virus is diagnosed and tested, treatment and expectations for those who suffer from the virus, and current and future studies on Herpes simplex type 2.

From the Paper:

"Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) cause prevalent, chronic infections that have serious outcomes in some individuals. Neonatal herpes may occur when the infant traverses the cervix during maternal genital herpes. Genital herpes is a major risk factor for human immunodeficiency virus type 1 transmission. Considerable efforts have been made to design and test vaccines for HSV, focusing on genital infection with HSV-2. Several protein subunit vaccines based on HSV-2 envelope glycoproteins have reached advanced-phase clinical trials. These antigens were chosen because they are the targets of neutralizing-antibody responses and because they elicit cellular immunity (Koelle 2003)."

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