This paper discusses the genetic model developed at Harvard to study this type of Hereditary Parkinsonism and proposes methods to design experiments, which can be performed towards finding a possible cure.
From the Paper:
"Alpha-synuclein is a 15-20KD protein, which has been shown in the cytosolic aggregates of Lewy body and dopamine positive cells in a rare dominant form of familial Parkinsons disease. The gene responsible is found to localize on human chromosome 4q21-q23.
Though this form of parkinsonism is DOPA treatment responsive, the work by the authors is a step in search of a complete cure and of a preventive measure if it can be designed using the transgenic fly. The usage of genetic fly can be of paramount importance in delineating the basic pathogenetic mechanism underlying the disease."
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