Scientific description of gene action & gene products.
Written in 2002; 2,025 words; 3 sources; $ 71.95
Paper Summary:
Scientific description of gene action & gene products. Describes research studies & methods. Bacterial clones. Phenotypes of genes; post embryonic phenotypes. Types & functions of genes. Genes responsbible for axonal guidance in the developing brain. Experiments & various techniques used by researchers. How genes mediate their effects on an organism.
From the Paper:
"Fraser et al (2000) used RNA-mediated interference (RNAi) to target approximately 90 percent of the predicted genes on C. elegans chromosome 1 by feeding these worms with a bacterium that expresses double-stranded RNA. RNAi transiently inhibits the activity of a gene by introducing double-stranded RNA (dsRNA) with a sequence specific to the target gene. Feeding these bacteria to the worms makes it possible to produce a library of dsRNA-expressing bacteria that can then be used for high-throughput genome-wide RNAi screens at very low cost. The only drawback to this technique is that RNAi does not efficiently inhibit all genes, so the method will miss some relevant genes.
Using such a library of bacteria which express dsRNA responding to genes on chromosome 1, this group were able to..."
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