Diovan: Implications and Nutrients

Paper Summary:

An ACE inhibitor works by making blood vessels relax and by preventing a chemical in the blood, angiotensin I, from being converted into a substance that increases salt and water retention in the body. This paper describes a particular ACE inhibitor, Diovan. Diovan restricts the nutrients of salt and water, preventing retention in the heart. Diovan has also been shown to decrease the likelihood of malignant ventricular arrhythmias. The paper discusses the use of Diovan in post-myocardial infarction. Side effects are noted and recommendations are listed for patients taking this medication.

From the Paper:

"A Medline search for all randomized trials of ACE inhibitor use in post-myocardial infarction for January 1978 through August 1997 was conducted for meta-analysis. Inclusion criteria consisted of randomized comparisons of ACE inhibitor and placebo treatment of acute MIs within 14 days after the event, studies that were conducted for a period of six weeks or longer with a blinded follow-up of six weeks or longer, and studies that reported the total, cardiovascular and sudden cardiac death mortalities."

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