Diabetes and Insulin Absorption

Paper Summary:

The writer explains that Diabetes Mellitus is the most common endocrine disorder, which is caused by either the loss of means of production of insulin or resistance to its effects. The writer points out that this disease has direct and indirect systemic effects, ultimately leading to the early demise of the individual. This paper outlines the pathogenesis of the disease by first discussing relevant anatomy and the normal physiology of the endocrine pancreas in relation to insulin. A review of new research regarding the pathogenesis of diabetes is also discussed.

From the Paper:

"Diabetes Mellitus is an endocrine disorder caused by either the loss of means of production of insulin or resistance to its effects. There are two types of diabetes, classified according to either of these causes. Type 1 (formerly insulin-dependent or juvenile-onset) diabetes, is caused by a profound lack or absence of insulin in the bloodstream. The source of insulin, the beta cells of the endocrine pancreas, is the target of autoimmune-mediated destruction. Type 2 (formerly non-insulin dependent or maturity-onset) diabetes, is caused most often by peripheral tissue resistance to insulin. This type of diabetes is more linked to a multifactorial inheritance pattern (i.e. can run in families) than Type 1 diabetes. More importantly, however, it manifests itself due to the adaptation of a sedentary lifestyle, leading to obesity and decreased tissue sensitivity to insulin."

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