Cholesterol and Cardiovascular Disease

Paper Summary:

Cardiovascular disease is one of the leading causes of mortality in the industrialized world. At the same time, high blood cholesterol is known to be a risk factor for heart disease. Decreasing total blood cholesterol can have a profound effect, reducing the incidence of coronary heart disease by close to 30%. Further, there is a wide variety of research that links blood cholesterol levels to heart disease and mortality. This paper presents a design for a study that aims to add to this body of evidence by investigating the impact of decreased cholesterol consumption on mortality from cardiovascular disease.

From the Paper:

"In each facility, 1,000 research subjects will be recruited using voluntary recruitment procedures. Advertisements for volunteers will be placed in local newspapers, community message boards, and clinic and emergency waiting rooms. Subjects will range in age upwards from 21 years of age. Subjects will not be excluded from the study on any medical or other grounds. This wide range of subjects and large sample size will allow researchers to correlate cholesterol intake with a number of other factors, including age, sex, race, place of residence, and other medical conditions."

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