This paper looks at a study conducted on mice which shows that the suppression of p53, done in conjunction with cancer therapy, may give patients some relief from unpleasant side-effects.
Written in 2002; 1,227 words; 4 sources; MLA; $ 41.95
Paper Summary:
The paper suggests that while the chemical inhibitor of p53 is suppressed, at the same time this treatment can allow for appropriate treatment to destroy p53-deficient cancer cells in a patient. The paper gives the chemical explanation for how the results were found in mice. The writer concludes with a discussion of the importance of this research for the future of cancer patients undergoing the intense treatment to fight the spread of the disease.
From the Paper:
"The p53 inhibitor had almost no protective effect if it was added up to 18 hours prior to, and removed immediately before, irradiation. A short, 3-hour treatment with PFT-alpha after irradiation had a pronounced protective effect on the cells, and a 24-hour incubation gave maximal protection. If PFT-alpha was added 3 hours after irradiation, it was not able to rescue the cells from radiation-induced damage. This suggests that ultraviolet radiation-induced apoptosis is significantly reduced within several hours, and completely eradicated within 24 hours of irradiation by PFT-alpha."
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