Caloric Restriction and Alzheimer's Disease

Paper Summary:

This paper explores the working hypothesis that caloric restriction may prevent Alzheimer's disease. In addition, the paper explores the idea that individuals with the ApoE genotype and a higher intake of calories have a higher risk of AD than those who do not carry the apoE4 allele.

From the Paper:

"Alzheimer's Disease is a form of dementia that is marked by the loss of mental ability and various cognitive functions. The disease usually occurs in old age and is not detectable at birth. (Robinson) There is no consensus on the cause of AD but researchers have found a genetic link in the development of the disorder. The Gale Encyclopedia of Medicine explains that there are various genes that are implicated in AD. One such gene is amyloid precursor protein (APP), which creates amlyloid. When there are mutations in this gene the result is often the early onset of Alzheimer's disease. It is also reported that most individuals that have Down syndrome also develop AD."

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